Investigation of the molecular mechanism underlying efficient systemic infection of the baculovirus
| Project/Area Number |
15H06155
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Insect science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kokusho Ryuhei 東京大学, 大学院農学生命科学研究科(農学部), 特任研究員 (90756537)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | バキュロウイルス / 全身感染 / BmNPV / arif-1 / カイコ / 気管 / 昆虫病理学 |
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| Outline of Final Research Achievements |
Baculoviruses are insect viruses that establish systemic infection in the body of host larvae. Previously we found that viral actin rearrangement-inducing factor 1 gene (arif-1) dramatically enhances systemic infection, but its molecular mechanism remains unknown. In this study, we introduced several mutations in arif-1 and identified amino acid regions responsible for its function. In addition, detailed observation of infected tissues revealed the previously unknown infection route that required ARIF-1.
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Report
(3 results)
Research Products
(3 results)
