Investigation of the molecular mechanism underlying efficient systemic infection of the baculovirus

Research Project

Project/Area Number	15H06155
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Insect science
Research Institution	The University of Tokyo
Principal Investigator	Kokusho Ryuhei 東京大学, 大学院農学生命科学研究科(農学部), 特任研究員 (90756537)
Project Period (FY)	2015-08-28 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	バキュロウイルス / 全身感染 / BmNPV / arif-1 / カイコ / 気管 / 昆虫病理学
Outline of Final Research Achievements	Baculoviruses are insect viruses that establish systemic infection in the body of host larvae. Previously we found that viral actin rearrangement-inducing factor 1 gene (arif-1) dramatically enhances systemic infection, but its molecular mechanism remains unknown. In this study, we introduced several mutations in arif-1 and identified amino acid regions responsible for its function. In addition, detailed observation of infected tissues revealed the previously unknown infection route that required ARIF-1.

Report

(3 results)