Research Project
Grant-in-Aid for Research Activity Start-up
Polytheonamide B is an ion-channel-forming 48-mer natural peptide that displays extraordinarily potent cytotoxicity. This study focuses on establishment of highly efficient solid-phase synthetic strategy for detailed functional and biological investigations of polytheonamide B and its analogues. Novel strategy of protective groups for component amino acids enabled full solid-phase total synthesis of polytheonamide B and its analogues. The newly established synthetic strategy significantly reduced the number of solution-phase synthetic steps and HPLC purification steps, leading to the efficient and facile synthesis of the total structure of polytheonamide B.
All 2017 2016 2015
All Journal Article (3 results) (of which Peer Reviewed: 3 results, Acknowledgement Compliant: 2 results, Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 2 results)
Chem. Eur. J.
Volume: 22 Issue: 47 Pages: 16912-16919
10.1002/chem.201604022
Org. Biomol. Chem.
Volume: 14 Issue: 18 Pages: 4199-4204
10.1039/c6ob00640j
Volume: 22 Issue: 10 Pages: 3370-3377
10.1002/chem.201504632