Exploring the mechanism of gamma-oscillation alterations in early stages of schizophrenia

Research Project

Project/Area Number	15H06166
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Psychiatric science
Research Institution	The University of Tokyo
Principal Investigator	Tada Mariko 東京大学, 医学部附属病院, 助教 (70758193)
Project Period (FY)	2015-08-28 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	統合失調症 / 脳波 / ガンマオシレーション / 脳神経疾患
Outline of Final Research Achievements	Ultra-high-risk (UHR) individuals, patients with recent-onset schizophrenia (ROS), and healthy controls(HC), were recruited. Spontaneous power of gamma oscillations and the auditory steady-state response (ASSR) were calculated by electroencephalography during 40-Hz auditory click trains.The 40-Hz ASSR was reduced in both the UHR and ROS groups compared to that in HC. Spontaneous power of gamma oscillations showed a increase in ROS. The 40Hz-ASSRs were correlated with spontaneous power of gamma oscillations in each groups.

Report

(3 results)