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Evaluation and prediction approach of cumulative dose distributions in consideration of structural change during radiotherapy.

Research Project

Project/Area Number 15H06168
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionThe University of Tokyo

Principal Investigator

Takahashi Wataru  東京大学, 医学部附属病院, 助教 (50755668)

Research Collaborator NAKAGAWA Keiichi  
YAMASHITA Hideomi  
HAGA Akihiro  
NAWA Kanabu  
SAKUMI Akira  
IMAE Toshikazu  
TAKENAKA Shigeharu  
MAGOME Taiki  
NAKANO Masahiro  
Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords放射線治療 / 放射線
Outline of Final Research Achievements

For patients with small lung tumor treated with intensity modulated radiation therapy, we established methodology for estimating actual delivered dose distributions taking account for respiratory motion. Based on logs including gantry angle, monitor unit, and the position of multi-leaf collimators during beam delivery, actual dose distribution on each respiratory phase was calculated. Then, accumulated dose distribution was simulated using deformable image registration. The present method successfully reconstructed accumulated dose distribution. The difference between this simulated dose and planning dose was reported in academic conference and will be reported as academic article.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (9 results)

All 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Long-term outcomes of single-session stereotactic radiosurgery for cerebellar arteriovenous malformation, with a median follow up of 10 years.2017

    • Author(s)
      Hasegawa H, Hanakita S, Shin M, Shojima M, Koga T, Takahashi W, Sakuramachi M, Nomoto AK, Saito N.
    • Journal Title

      World Neurosurg.

      Volume: 98 Pages: 314-322

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Value of the Epstein-Barr Virus and p16 Status in Patients with Nasopharyngeal Carcinoma: A Single-Centre Study in Japan.2017

    • Author(s)
      Saito Y, Ushiku T, Omura G, Yasuhara K, Yoshida M, Takahashi W, Ando M, Fukayama M, Yamasoba T
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec.

      Volume: 78(6) Issue: 6 Pages: 334-343

    • DOI

      10.1159/000455901

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long-Term Outcomes of Single-Session Stereotactic Radiosurgery for Cerebellar Arteriovenous Malformation, with a Median Follow-Up of 10 Years2016

    • Author(s)
      Nomoto AK, Takahashi W (Corresponding Author), Yamashita H, Haga A, Yoda K, Nakagawa K
    • Journal Title

      BJR Case Rep

      Volume: 98 Pages: 314

    • DOI

      10.1016/j.wneu.2016.10.137

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction Chemotherapy for p16 Positive Oropharyngeal Squamous Cell Carcinoma2016

    • Author(s)
      Yuki Saito, MD, PhD; Mizuo Ando, MD, PhD; Go Omura, MD; Kazuo Yasuhara, MD; Masafumi Yoshida, MD, PhD; Wataru Takahashi, MD, PhD; Tatsuya Yamasoba, MD, PhD
    • Journal Title

      Laryngoscope Investigative Otolaryngology

      Volume: 未定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of a Post-analysis Method for Cumulative Dose Distribution in Stereotactic Body Radiotherapy2016

    • Author(s)
      今江 禄一, 芳賀 昭弘, 早乙女 直也, 木田 智士, 中野 正寛, 竹中 重治, 竹内 幸浩, 白木 尚, 矢野 敬一, 山下 英臣, 中川 恵一, 大友 邦
    • Journal Title

      Japanese Journal of Radiological Technology

      Volume: 72 Issue: 3 Pages: 251-260

    • DOI

      10.6009/jjrt.2016_JSRT_72.3.251

    • NAID

      130005137459

    • ISSN
      0369-4305, 1881-4883
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Changes in pulmonary function after single fraction carbon ion radiotherapy for stage I NSCLC2016

    • Author(s)
      W. Takahashi, N. Yamamoto, M. Nakajima, M. Karube, H. Yamashita, K. Nakagawa, H. Tsuji, T. Kamada
    • Organizer
      ESTRO 35
    • Place of Presentation
      Turin(Italy)
    • Year and Date
      2016-04-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Definitive Radiotherapy for Early Stage (cT1-T2) Glottic Squamous Cell Carcinoma: the University of Tokyo Hospital Experience2016

    • Author(s)
      W. Takahashi, R. Kobayashi, M. Sakuramachi, T. Kiritoshi, K. Yamamoto, H. Igaki, H. Yamashita, and K. Nakagawa
    • Organizer
      第75回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-04-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] FFF-VMAT-SBRTにおける 非剛体レジストレーションを用いた4次元線量解析2016

    • Author(s)
      髙橋 渉, 今江 禄一, 竹中 重治, 山下 英臣, 中川 恵一, 芳賀 昭弘
    • Organizer
      日本放射線腫瘍学会第29回学術大会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Definitive Radiotherapy for Early Stage (cT1-T2) Glottic Squamous Cell Carcinoma: the University of Tokyo Hospital Experience2016

    • Author(s)
      髙橋 渉, 山下 英臣, 櫻町 円香、中川 恵一
    • Organizer
      第75回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2016 Annual Research Report

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Published: 2015-08-26   Modified: 2018-03-22  

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