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Elucidation of the processing mechanism of reactive oxygen species in the inner ear in MnSOD genetically modified animals

Research Project

Project/Area Number 15H06174
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionThe University of Tokyo

Principal Investigator

Kinoshita Makoto  東京大学, 医学部附属病院, 登録診療員 (10755648)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsMnSOD / SOD2 / 騒音性難聴 / 酸化ストレス / ミトコンドリア / MnSOD / SOD2
Outline of Final Research Achievements

Manganese superoxide dismutase (MnSOD) is one of the antioxidant enzymes acting within the mitochondria. To investigate the pathological role of mitochondrial antioxidant stress in the cochlea, we generated systemic MnSOD heterozygous knockout (Sod2+/-) mice, and investigated hearing loss and histological damage after noise exposure.
The mean thresholds of auditory brainstem responses were significantly worse in the Sod2+/- group on post-noise days 7 and 14. Histologically, compared with control group, outer hair cell survival rate in the Sod2+/- group was significantly decreased in all cochlear turns.
We showed that delay of hearing recovery and outer hair cell damage occur after noise exposure with decreasing MnSOD. These findings suggest that MnSOD has important role to reduce reactive oxygen species in hair cell, thereby protecting from noise induced hearing loss.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (4 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Manganese superoxide dismutase influences the extent of noise-induced hearing loss in mice.2017

    • Author(s)
      Tuerdi A, Kinoshita M, Kamogashira T, Fujimoto C, Iwasaki S, Shimizu T, Yamasoba T
    • Journal Title

      Neurosci Lett

      Volume: 642 Pages: 123-128

    • DOI

      10.1016/j.neulet.2017.02.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 騒音暴露による内耳酸化ストレスがMnSODヘテロ欠損マウスの聴覚に及ぼす影響2016

    • Author(s)
      Aynur Turdi、木下淳、藤本千里、岩崎真一、山岨達也
    • Organizer
      第16回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] Mn-SOD affects Noise Induced Hearing Loss2016

    • Author(s)
      Aynur Turdi, Makoto Kinoshita, Chisato Fujimoto, Shinichi Iwasaki, Tatsuya yamasoba
    • Organizer
      Association for Research in Otolaryngology, 39th Annual Mid Winter Meeting
    • Place of Presentation
      サンディエゴ(USA)
    • Year and Date
      2016-02-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mn-SOD affects Noise Induced Hearing Loss2015

    • Author(s)
      Aynur Turdi, Makoto Kinoshita, Chisato Fujimoto, Shinichi Iwasaki, Tatsuya yamasoba
    • Organizer
      13th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
    • Place of Presentation
      一ツ橋ホール(東京)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2015-08-26   Modified: 2018-03-22  

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