Toward development of a silicon-bridged coelenterazine derivative for in vivo imaging
| Project/Area Number |
15H06180
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical biology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | セレンテラジン / ピラジン / クロスカップリング反応 / 環化反応 / Sandmeyer反応 / 鈴木-宮浦クロスカップリング / 分子イメージング / 有機合成化学 / 根岸クロスカップリング反応 / 鈴木-宮浦クロスカップリング反応 |
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| Outline of Final Research Achievements |
We have studied on new synthetic methods of coelenterazine analogues with the aim of development of a near-infrared bioluminescence system. As the results, we found that four substituents could be introduced into easily accessible 2-amino-3,5-dibromo-6-chloropyrazine via successive palladium-catalyzed cross-coupling reactions. Moreover, a phenyl group equipped with a free hydroxy group at the ortho position was also applicable for the cross-coupling reaction. The hydroxy group could be transformed into a triflyloxy group, which was found to be useful for construction of a cyclic system containing the pyrazine ring.
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Report
(3 results)
Research Products
(10 results)
