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Analysis on circular RNAs potentially related to spinocerebellar ataxia type 31.

Research Project

Project/Area Number 15H06181
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Sato Nozomu  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (30754551)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords環状RNA / Non-coding RNA / 神経変性疾患 / 脊髄小脳失調症31型 / Alu / microsatellite / マイクロサテライト伸長 / non-coding RNA
Outline of Final Research Achievements

Circular RNAs (circRNAs) are a type of non-coding RNAs whose functions are yet to be unveiled. Intronic Alu sequences have been shown to be important for the systhesis of circRNAs. We aimed to clarify the effect of microsatellite expansions associated with Alu, which sometimes result in neurodegenerative disorders, on the synthesis and metabolism of circRNAs. The mutation responsible for spinocerebellar ataxia type 31 (SCA31) is an example of such microsatellite expansions, and we tried to identify the effect of the SCA31 mutation on potential circRNAs orginating from BEAN1 and TK2, the genes harboring the SCA31 mutation. We conducted RT-PCR on brain specimens of SCA31 autopsy samples and of mutant human BEAN1 transgenic mice in various conditions, but we could not found DNA fragments resulting from potential circRNAs of BEAN1 and TK2. We could not obtain findings suggesting the involvement of circRNA(s) in the pathogenesis of SCA31.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (1 results)

All 2017

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA312017

    • Author(s)
      Taro Ishiguro, Nozomu Sato, Morio Ueyama, Nobuhiro Fujikake, Chantal Sellier, Akemi Kanegami, Eiichi Tokuda, Bita Zamiri, Terence Gall-Duncan, Mila Mirceta, Yoshiaki Furukawa, 他8名
    • Journal Title

      Neuron

      Volume: 94 Issue: 1 Pages: 108-124

    • DOI

      10.1016/j.neuron.2017.02.046

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2015-08-26   Modified: 2018-03-22  

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