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Periodontal tissue regeneration using controlled release of fibroblast growth factor-2 by electrostatic binding with scaffold

Research Project

Project/Area Number 15H06190
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

hoshi shu  東京医科歯科大学, 歯学部附属病院, 非常勤講師 (70757210)

Research Collaborator AKIZUKI Tatsuya  
MATSURA Takanori  
IZUMI Yuichi  
Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords線維芽細胞増殖因子-2 / 徐放化 / 歯周組織再生 / 歯周病 / FGF-2 / 歯学 / 再生医学 / 再生 / 細胞増殖因子
Outline of Final Research Achievements

Experiments were carried out on periodontal defect model using beagle dogs. Controlled release of fibroblast growth factor-2 by electrostatic binding with β-TCP acidic gelatin sponge was effective in root cover to gingival recession. Combined use of acidic β-TCP gelatin sponge and fibroblast growth factor-2 was effective for regenerating alveolar bone compared to the combination of basic β-TCP gelatin sponge and fibroblast growth factor-2.In periodontal tissue regeneration therapy, the combination of β-TCP gelatin sponge and fibroblast growth factor-2 was not effective compared with the combination of β-TCP particles and fibroblast growth factor-2.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (4 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Biodegradable gelatin/beta-tricalcium phosphate sponges incorporating recombinant human fibroblast growth factor-2 for treatment of recession-type defects: A split-mouth study in dogs.2017

    • Author(s)
      Shujaa Addin A, Akizuki T, Hoshi S, Matsuura T, Ikawa T, Fukuba S, Matsui M, Tabata Y, Izumi Y.
    • Journal Title

      J Periodontal Res. 2017

      Volume: 印刷中 Issue: 5 Pages: 863-871

    • DOI

      10.1111/jre.12456

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ridge Preservation After Tooth Extraction With Buccal Bone Plate Deficiency Using Tunnel Structured β-Tricalcium Phosphate Blocks: A 2-Month Histologic Pilot Study in Beagle Dogs.2016

    • Author(s)
      Ikawa T, Akizuki T, Matsuura T, Hoshi S, Ammar SA, Kinoshita A, Oda S, Izumi Y
    • Journal Title

      journal of periodontology

      Volume: 87(2) Issue: 2 Pages: 175-183

    • DOI

      10.1902/jop.2015.150246

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] rhFGF-2/gelatin-βTCP in the treatment of gingival recessions in dogs.2016

    • Author(s)
      Ammar SA, Hoshi S, Matsuura T, Ikawa T, Maruyama K, Ono W, Fukuba S, Izumi Y.
    • Organizer
      The 102th meeting of American Academy of Periodontology
    • Place of Presentation
      San Deigo
    • Year and Date
      2016-09-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of rhFGF-2 Combined with Gelatin/β-TCP Sponge on Root Coverage: a Pilot Study in Beagle Dogs2015

    • Author(s)
      Shujaa Addin Ammar, Tatsuya Akizuki, Shu Hoshi, Takanori Matsuura, Takahiro Ikawa, Kiichi Maruyama, Wataru Ono, Makoto Matsui, Yasuhiko Tabata, Yuichi Izumi.
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report

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Published: 2015-08-26   Modified: 2018-03-22  

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