Development of an assembly method for whole genomes of polyploid organisms

Research Project

Project/Area Number	15H06209
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Genome biology
Research Institution	Tokyo Institute of Technology
Principal Investigator	Kajitani Rei 東京工業大学, 生命理工学院, 助教 (40756706)
Project Period (FY)	2015-08-28 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	多倍体 / ゲノム / de novo アセンブリ / de novoアセンブリ / アルゴリズム
Outline of Final Research Achievements	Polyploidization are widely observed for brewing yeasts and agricultural plants, and genome analysis of these organisms can be valuable for industries. However, multiple homologous chromosomes that are similar to each other require a novel and effective algorithm. In this research, I developed a tool to determine backbone structures of polyploid genomes (consensus sequences) and each homologous chromosome sequence (haplotype) separately.