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Blocking the arylhydrocarbon receptor for cancer immunotherapy

Research Project

Project/Area Number 15H06247
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Tumor therapeutics
Research InstitutionGifu University

Principal Investigator

Ninomiya Soranobu  岐阜大学, 医学部附属病院, 助教 (90444281)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords腫瘍免疫 / アリルハイドロカーボン受容体 / キヌレニン / 癌 / 免疫
Outline of Final Research Achievements

IDO is an intracellular enzyme proceed the essential amino acid tryptophan metabolism. Accumulation of tryptophan derivatives such as kynurenine blocks antigen-specific T-cell proliferation and induces T-cell death. A recent study indicated that kynurenine was an endogenous ligand of aryl hydrocarbon receptor (AhR). We collected PBMCs from healthy blood donors, and bone marrow samples from multiple myeloma patients at first diagnosis. The cells were activated with anti-CD3 and anti-CD28 Abs. We measured the expression of AhR in activated T-cells using by flow cytometry.Kynurenine produced by IDO, induce inhibitory signal in T-cells through the AhR. Anti-PD-1 and anti-CTLA-4 therapies, which block directly the inhibitory signal in T-cells, have been getting some clinical benefits against such as melanoma and Hodgkin lymphoma. Therefore, the AhR in T cells might be a target for IDO-positive hematological malignancies.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (8 results)

All 2016 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Journal Article] Serum concentrations of l-kynurenine predict clinical outcomes of patients with peripheral T-cell lymphoma, not otherwise specified.2016

    • Author(s)
      Shibata Y, Hara T, Matsumoto T, Nakamura N, Nakamura H, Ninomiya S, Kitagawa J, Goto N, Nannya Y, Ito H, Kito Y, Miyazaki T, Takeuchi T, Saito K, Seishima M, Takami T, Moriwaki H, Shimizu M, Tsurumi H.
    • Journal Title

      Hematological Oncology

      Volume: - Issue: 4 Pages: 637-644

    • DOI

      10.1002/hon.2318

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic value of the combination of serum l-kynurenine level and indoleamine 2,3-dioxygenase mRNA expression in acute myeloid leukemia.2016

    • Author(s)
      Hara T, Matsumoto T, Shibata Y, Nakamura N, Nakamura H, Ninomiya S, Kitagawa J, Nannya Y, Shimizu M, Ito H, Saito K, Tsurumi H.
    • Journal Title

      Leukemia Lymphoma

      Volume: 57(9) Issue: 9 Pages: 2208-2211

    • DOI

      10.3109/10428194.2015.1128541

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of the combination of serum l-kynurenine level and indoleamine 2,3-dioxygenase mRNA expression in acute myeloid leukemia.2016

    • Author(s)
      Hara T, Matsumoto T, Shibata Y, Nakamura N, Nakamura H, Ninomiya S, Kitagawa J, Nannya Y, Shimizu M, Ito H, Saito K, Tsurumi H.
    • Journal Title

      Hematology Oncology

      Volume: 21 Issue: 3 Pages: 1-4

    • DOI

      10.1002/hon.2285

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Role of Indoleamine 2,3-Dioxygenase in Diethylnitrosamine-Induced Liver Carcinogenesis2016

    • Author(s)
      Shibata Y, Hara T, Nagano J, Nakamura N, Ohno T, Ninomiya S, Ito H, Tanaka T, Saito K, Seishima M, Shimizu M, Moriwaki H, Tsurumi H
    • Journal Title

      Leukemia Lymphoma

      Volume: 11 Issue: 1 Pages: 4-11

    • DOI

      10.1371/journal.pone.0146279

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] 腫瘍微小環境中T細胞におけるアリルハイドロカーボン受容体の重要性2016

    • Author(s)
      二宮 空暢  中村 信彦  北川 順一  原 武志  清水 雅仁  鶴見 寿
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      神奈川県・横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] The Roles of Aryl Hydrocarbon Receptor in T cells at IDO-positive Tumor Microenvironment2016

    • Author(s)
      二宮 空暢  中村 信彦  北川 順一  原 武志  清水 雅仁  鶴見 寿
    • Organizer
      第58回アメリカ血液学会総会
    • Place of Presentation
      アメリカ・サンディエゴ
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 岐阜血液疾患研究グループホームページ

    • URL

      http://seesaawiki.jp/ghsp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] Gifu Hematology Study Group

    • URL

      http://seesaawiki.jp/ghsp/

    • Related Report
      2015 Annual Research Report

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Published: 2015-08-26   Modified: 2018-03-22  

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