| Project/Area Number |
15H06254
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
bunai tomoyasu 浜松医科大学, 光尖端医学教育研究センター, 特任助教 (20754188)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | レビー小体型認知症 / ミクログリア活性 / 脳神経疾患 / 痴呆 / 神経科学 / 老化 / 放射線 |
|---|
| Outline of Final Research Achievements |
The presence of misfolded proteins such as alpha-synuclein, key players in the pathogenesis of dementia with Lewy bodies (DLB), can lead to activation of microglia in the brain. Indeed, microglia play a central role in neuroinflammation in the brain, the neuroinflammation is reported to relate to the neuronal degeneration in DLB. We report microglial activation in DLB patients using PET with [11C] DPA713, and examine the relationship between microglial activation and neuropsychiatric symptoms.
The DLB patients showed a significant elevation of [11C]DPA713 BPND in the whole brain, especially in the occipital regions. Correlations between NPI subscore (hallucination) and [11C]DPA713 BPND were found in the occipital, temporo-parietal cortical regions.
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