Halogen-based Lewis acid-chiral Lewis base catalysts for enantioselective chlorocyclization and fluorocyclization
| Project/Area Number |
15H06266
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Synthetic chemistry
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | ハロ環化反応 / クロロ環化反応 / フルオロ環化反応 / Lewis塩基 / エナンチオ選択的反応 / カルコゲン触媒 / カルコゲンLewis塩基 / エナンチオ選択的 |
|---|
| Outline of Final Research Achievements |
Enantioselective carbon-halogen bond forming reaction using electrophilic halogen is an useful method for synthesis of enantio-enriched halogenated organic compounds. In this study, we focused on Lewis base-Lewis acid cooperative catats for capturing halogens in order to control their reactivities. In the presence of chalcogen Lewis base-halogen-based Lewis acid, highly reactive halogen could be used for halocyclization without producing byproducts. Moreover, we demonstrated enantioselective chlorocyclization.
|
Report
(3 results)
Research Products
(8 results)
