| Project/Area Number |
15H06274
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Applied microbiology
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 応用微生物 / 環境 / 細菌 / 有機ヒ素分解 / 応用微生物学 |
|---|
| Outline of Final Research Achievements |
Organoarsenicals have been used for agricultural purposes in various countries. However, because they are degraded by microbes into more toxic inorganic arsenicals in the environment, spreading of the environmental pollution by the continued uses has been concerned. Although metabolisms of organoarsenicals have been reported also in higher animals, the molecular mechanisms either for microbes or animals have not been well understood yet. In this study, therefore, I attempted to identify novel genes related to organoarsenical degradation. Although no novel genes were identified, I could identify a new additional step for degradation pathways for specific organoarsenicals by microbes. In addition, I performed further biochmical and structural biological analyses on the organoarsenical degrading enzyme that I previously identified and clarified the detail of the unique reaction mechanism at molecular level.
|
