| Project/Area Number |
15H06279
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Nagoya University |
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Principal Investigator |
Luo Chenhong 名古屋大学, 医学系研究科, 招へい教員 (40759627)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Glypican 3 / dendritic cells / Lamp-1 / signal peptide / アンプリコン / GCP / LAMP / 樹状細胞 / ウイルス / 腫瘍 / HF10 / GPC3 |
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| Outline of Final Research Achievements |
In this study, our results indicated that 1. HF10-package amplicon, which expresses tumor associated antigen glypican3 (GPC3), induced the antigen specific immune response through infected dendritic cells and inhibited the tumor growth in mouse ovarian cancer model. 2. In mouse peritoneal tumor seeding model, through prophylactic vaccination, we found that the dosing i.p. had the best antitumor effect among i.p., i.v., and s.c. dosing routes. 3. The chimera of Lamp-1 signal peptide and GPC3 induced GPC3 specific immune response through dendritic cell presentation more strongly than GCP3.
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