| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Intrauterine infection is a common trigger for preterm birth and is also a risk factor for the subsequent development of neurodevelopmental abnormalities in the neonates. Hydrogen water (HW) has been already reported to have both antioxidant and anti-inflammatory action. In this study, it is investigated whether effected uterus tissues in Lipoporysaccharide(LPS)-induced preterm models by Hydrogen water(HW). HW+LPS group was decreased delivery within 24 hours after LPS administration compared with LPS group. IL-6 and TNF-alpha was significantly increased in LPS group compared with control groups, but suppressed in HW+LPS group. Contraction-associated proteins(CAPs), cox-2, connexin43, and oxytocin receptor, were also increased in LPS group compared with control group, but suppressed in HW+LPS group. Metalloproteinase-3(MMP-3), Endothelin-1(ET-1) were same result, too. Futhermore, Hydrogen water did not show fetal damage.
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