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Analysis of the effect of microRNA-33 on bone marrow function and chronic inflammation

Research Project

Project/Area Number 15H06335
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Cardiovascular medicine
Research InstitutionKyoto University

Principal Investigator

Baba Osamu  京都大学, 医学研究科, 医員 (30758446)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsマイクロRNA / 単球 / HDLコレステロール / ABCA1 / HMGA2 / マイクロRNA-33 / 炎症性単球 / 造血幹細胞 / 循環器 / 免疫
Outline of Final Research Achievements

In the present study, we analyzed the effect of microRNA (miR)-33 on leukocyte population and bone marrow function. As a result, the expression of High mobility group AT-hook 2 (HMGA2) targeted by miR-33 was increased in hematopoietic stem cells in miR-33 deficient mice, which reduced their apoptosis and subsequently increased hematopoietic stem cell, myeloid progenitor and monocyte population in bone marrow. On the other hand, miR-33 is known to increase HDL cholesterol by targeting ATP-binding cassette transporter A1 (ABCA1). We also demonstrated that this increase in HDL cholesterol suppressed the emigration of monocytes from bone marrow to peripheral blood, which decreased peripheral inflammatory monocytes in miR-33 deficient mice.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (2 results)

All 2016

All Presentation (2 results)

  • [Presentation] マイクロRNA-33の骨髄機能および慢性炎症における役割2016

    • Author(s)
      馬場 理、堀江 貴裕、伯野 大彦、中島 康弘、桑原 康秀、中尾 哲史、出原 正康、宇佐美 俊輔、西賀 雅隆、西野 共達、井手 裕也、中関 典子、小山 智史、木村 昌弘、花田 律子、木村 剛、尾野 亘
    • Organizer
      Research PlaNet 2016
    • Place of Presentation
      イイノホール&カンファレンスセンター(東京都千代田区内幸町2-1-1)
    • Year and Date
      2016-05-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] マイクロRNA-33の骨髄機能および慢性炎症における役割2016

    • Author(s)
      馬場 理
    • Organizer
      Research PlaNet 2016
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2016-05-28
    • Related Report
      2015 Annual Research Report

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Published: 2015-08-26   Modified: 2018-03-22  

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