resting state brain functional connectivity in gambling disorder

• Project/Area Number: 15H06336
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Kyoto University
• Principal Investigator: Tsurumi Kosuke 京都大学, 医学研究科, 助教 (20760854)
• Research Collaborator: KAWADA Ryosaku ; TAKEUCHI Hideaki ; MURAO Takuro ; TAKEMURA Ariyoshi ; FUJIMOTO Atsushi
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 神経科学 / ギャンブル障害 / 依存症 / MRI / ゲノム

Outline of Final Research Achievements

In this project, we investigated the association between functional and structural brain alteration, especially resting state functional alteration, of gambling disorder (GD) patients and clinical characteristics or gene variant to elucidate pathophysiology of GD. We found a need to classify GD into two subtypes, and revealed a part of brain network dysfunction in GD. Our findings would contribute to elucidate pathophysiology of GD.

Research Products

• [Journal Article] Common and differential brain abnormalities in gambling disorder subtypes based on risk attitude. (2017)
  • Author(s): Takeuchi H, Tsurumi K, Murao T, Takemura A, Kawada R, Urayama SI, Aso T,Sugihara GI, Miyata J, Murai T, Takahashi H.
  • Journal Title: Addictive Behaviors Volume: 69 Pages: 48-54
  • DOI: 10.1016/j.addbeh.2017.01.025
  • Peer Reviewed / Open Access
• [Journal Article] Deficit of State-Dependent Risk-Attitude Modulation in Gambling Disorder. (2017)
  • Author(s): Atsushi Fujimoto, Kosuke Tsurumi, Ryosaku Kawada, Takuro Murao, Hideaki Takeuchi, Toshiya Murai, Hidehiko Takahashi
  • Journal Title: Translational Psychiatry Volume: 7
  • NAID: 120006027095
  • Peer Reviewed / Open Access
• [Journal Article] Heterogeneity of Loss Aversion in Pathological Gambling. (2015)
  • Author(s): Takeuchi,H., Kawada, R., Tsurumi, K., Yokoyama, N., Takemura, A., Murao, T., Murai, T. & Takahashi, H.
  • Journal Title: Journal of Gambling Study Volume: Epub ahead of print Issue: 4 Pages: 1143-1154
  • DOI: 10.1007/s10899-015-9587-1
  • NAID: 120005997647
  • Peer Reviewed / Open Access
• [Presentation] ギャンブル障害の研究と臨床 (2017)
  • Author(s): 鶴身孝介
  • Organizer: 第18回サイコセラピー学会
  • Place of Presentation: 兵庫医科大学（兵庫県西宮市）
  • Year and Date: 2017-03-25
  • Invited
• [Presentation] ギャンブル障害の損失回避性に基づいたサブタイプにおける脳構造の違いについて (2017)
  • Author(s): 竹内秀暁、鶴身孝介、村尾託朗、竹村有由、川田良作、浦山慎一、麻生俊彦、杉原玄一、宮田淳、村井俊哉、高橋英彦
  • Organizer: 平成29年度日本ヒト脳機能マッピング学会
  • Place of Presentation: 京都大学100周年時計台記念館（京都市左京区）
  • Year and Date: 2017-03-09
• [Presentation] 病的賭博における強化学習の神経基盤 (2016)
  • Author(s): 村尾託朗 鶴身孝介 竹内秀暁 川田良作 水田弘人 佐々木仁 村井俊哉 高橋英彦
  • Organizer: 平成28年度宮古島神経科学カンファレンス
  • Place of Presentation: ホテルブリーズベイマリーナ（沖縄県宮古島市）
  • Year and Date: 2016-11-11
• [Presentation] 嗜癖物質への早期暴露や摂取量、嗜癖罹病期間による脳の影響 (2016)
  • Author(s): 鶴身孝介
  • Organizer: 第51回日本アルコール・アディクション医学会学術総会
  • Place of Presentation: タワーホール船堀 （東京都江戸川区）
  • Year and Date: 2016-10-07
• [Presentation] 病的賭博における強化学習の神経基盤 (2016)
  • Author(s): 村尾託朗 鶴身孝介 竹内秀暁 川田良作 竹村有由 村井俊哉 高橋英彦
  • Organizer: 平成28年度日本生物学的精神医学会
  • Place of Presentation: 福岡国際会議場（福岡市博多区）
  • Year and Date: 2016-09-08
• [Presentation] ltered resting state functional connectivity between the insula and DMN region reflects duration of illness in gambling disorder patients. (2016)
  • Author(s): Tsurumi K, Aso T, Kawada R, Hazama M, Miyata J, Fukuyama H, Murai T, Takahashi H
  • Organizer: The International Society for Biomedical Research on Alcoholism (ISBRA) and the European Society for Biomedical Research on Alcoholism (ESBRA) Berlin 2016 World Congress on Alcohol and Alcoholism
  • Place of Presentation: Technische Universitat Berlin, Berlin, Germany
  • Year and Date: 2016-09-02
  • Int'l Joint Research
• [Presentation] Flexible Modulation of Risk Attitude during Decision-Making under Quota and Its Impairments in Gambling Disorders (2016)
  • Author(s): Atsushi Fujimoto, Kosuke Tsurumi, Ryosaku Kawada, Takuro Murao, Hideaki Takeuchi, Toshiya Murai, Hidehiko Takahashi
  • Organizer: 6th Motivation and Cognitive Control (MCC) Symposium
  • Place of Presentation: St.Andrews University (Scotland)
  • Year and Date: 2016-08-24
  • Int'l Joint Research
• [Presentation] Resting state functional connectivity between insula and large-scale brain networks in gambling disorder patients. (2016)
  • Author(s): Kosuke Tsurumi, Toshihiko Aso, Ryosaku Kawada, Masaaki Hazama, Genichi Sugihara, Jun Miyata, Hidenao Fukuyama, Toshiya Murai, Hidehiko Takahashi
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2016-07-20
• [Presentation] Resting state functional connectivity between insula and DMN region in gambling disorder patients (2016)
  • Author(s): Kosuke Tsurumi, Toshihiko Aso, Ryosaku Kawada, Masaaki Hazama, Jun Miyata, Hidenao Fukuyama, Toshiya Murai, Hidehiko Takahashi
  • Organizer: 22th annual Meeting of theOrganization for Human Brain Mapping
  • Place of Presentation: Palexbo Exhibition and Congress Center Geneva, Switzerland
  • Year and Date: 2016-06-26
  • Int'l Joint Research
• [Presentation] ギャンブル障害の脳画像研究 (2016)
  • Author(s): 鶴身孝介
  • Organizer: 第112回日本精神神経学会学術総会
  • Place of Presentation: 幕張メッセ（千葉市）
  • Year and Date: 2016-06-02
• [Presentation] ギャンブル障害の脳画像研究 (2016)
  • Author(s): 鶴身孝介
  • Organizer: 第3回日本依存症医療研究会
  • Place of Presentation: 兵庫県立光風病院 （神戸市）
• [Presentation] ギャンブル障害患者の島皮質をseedとした安静時脳機能結合について (2015)
  • Author(s): 鶴身孝介, 川田良作, 村尾託朗, 竹内秀暁, 竹村有由, 挾間雅章, 村井俊哉, 高橋英彦
  • Organizer: 平成27年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 神戸国際会議場（神戸市中央区）
  • Year and Date: 2015-10-11
• [Presentation] 病的賭博における強化学習の神経基盤 (2015)
  • Author(s): 村尾託朗 鶴身孝介 竹内秀暁 川田良作 竹村有由 村井俊哉 高橋英彦
  • Organizer: 平成27年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 神戸国際会議場（神戸市中央区）
  • Year and Date: 2015-10-11
• [Presentation] The effect of Taq1A polymorphism on the white matter integrity in gambling disorder. (2015)
  • Author(s): Ariyoshi Takemura, Masanori Isobe, Jun Miyata, Kosuke Tsurumi, Ryosaku Kawada, Naoto Yokoyama, Masaaki Hazama, Toshiya Murai, Hidehiko Takahashi
  • Organizer: International Society of Addiction Medicine(ISAM) 2015
  • Place of Presentation: Caird Hall, Dundee Scotland
  • Year and Date: 2015-10-05
  • Int'l Joint Research
• [Presentation] ギャンブル障害患者の安静時脳機能結合について (2015)
  • Author(s): 鶴身孝介, 川田良作, 狭間雅章, 村尾託朗, 竹内秀暁, 竹村有由, 杉原玄一, 宮田淳, 村井俊哉, 高橋英彦
  • Organizer: 第37回 日本生物学的精神医学会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2015-09-24