Prognostic factors of diffuse lower-grade gliomas

• Project/Area Number: 15H06339
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurosurgery
• Research Institution: Kyoto University
• Principal Investigator: Aoki Kosuke 京都大学, 医学研究科, 研究員 (10759773)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 神経膠腫 / 遺伝子異常 / 予後因子 / 予後不良因子 / 脳神経疾患 / ゲノム

Outline of Final Research Achievements

Diffuse lower-grade gliomas (LGGs) are genetically classified into three distinct subtypes based on IDH mutation and 1p/19q codeletion. However, the subtype-specific effects of additional genetic lesions on survival are largely unknown.　In this study, we revealed the subtype-specific effects of genetic alterations and clinicopathological factors on survival in each LGG subtype, using Cox proportional-hazard regression modeling in our cohort. These results were largely confirmed using the dataset from The Cancer Genome Atlas. Our findings suggest that subtype-specific genetic lesions could stratify patients for better management.

Research Products

• [Presentation] Genetic subtype-specific prognostic significance of genetic alterations in lower-grade gliomas (2016)
  • Author(s): Kosuke Aoki, Hiromichi Suzuki, Hideo Nakamura, Keitaro Matsuo, Kazuya Motomura, Fumiharu Ohka, Masahiro Mizoguchi, Yasutomo Momii, Yoshihiro Muragaki, Reiko Watanabe, Ichiro Ito, Satoru Miyano, Toshihiko Wakabayashi, Atsushi Natsume, Seishi Ogawa
  • Organizer: American Asspociation for cancer research 2016 annual meeting
  • Place of Presentation: New Orleans, TX, USA
  • Year and Date: 2016-04-16
  • Int'l Joint Research
• [Presentation] Comprehensive mutational and cytogenetic analysis revealed prognostic impacts of genetic alterations in grade II and III gliomas (2016)
  • Author(s): K Aoki, A Natsume, H Suzuki, S Ogawa, T Wakabayashi
  • Organizer: KEYSTONE SYMPOSIA THE CANCER GENOME (Q1)
  • Place of Presentation: Alberta, Canada
  • Year and Date: 2016-02-07
  • Int'l Joint Research
• [Presentation] Genetic subtype-specific prognostic significance of genetic alterations in lower-grade gliomas (2016)
  • Author(s): Kosuke Aoki, Hiromichi Suzuki, Hideo Nakamura, Keitaro Matsuo, Kazuya Motomura, Fumiharu Ohka, Masahiro Mizoguchi, Yasutomo Momii, Yoshihiro Muragaki, Reiko Watanabe, Ichiro Ito, Satoru Miyano, Toshihiko Wakabayashi, Atsushi Natsume, Seishi Ogawa
  • Organizer: American Asspociation for cancer research 2016 annual meeting
  • Place of Presentation: New Orleans, USA
  • Int'l Joint Research
• [Presentation] 大規模ゲノム解析から明らかとなったgrade II, III 神経膠腫における遺伝学的予後予測因子 (2016)
  • Author(s): 青木恒介、鈴木啓道、中村英夫、松尾恵太郎、本村和也、大岡史治、椎名諭、山本高士、溝口昌弘、籾井泰朋、村垣善浩、眞田昌、宮野悟、若林俊彦、小川誠司、夏目敦至
  • Organizer: 第75回日本脳神経外科学会学術総会
  • Place of Presentation: 福岡
• [Presentation] Prognostic implications of genetic alterations from comprehensive genetic profiling in diffuse lower-grade gliomas (2016)
  • Author(s): Kosuke Aoki, Hiromichi Suzuki, Keitaro Matsuo, Keisuke Kataoka, Teppei Shimamura, Yasunobu Nagata, Tetsuichi Yoshizato, Masashi Sanada, Satoru Miyano, Toshihiko Wakabayashi, Atsushi Natsume and Seishi Ogawa
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Comprehensive mutational and cytogenetic analysis revealed genetic prognostic factors in grade II and III gliomas. (2016)
  • Author(s): Kosuke Aoki, Hiromichi Suzuki, Hideo Nakamura, Keitaro Matsuo, Kazuya Motomura, Fumiharu Ohka, Masahiro Mizoguchi, Yasutomo Momii, Yoshihiro Muragaki, Reiko Watanabe, Ichiro Ito, Toshihiko Wakabayashi, Atsushi Natsume, Seishi Ogawa
  • Organizer: 21th ANNUAL SOCIETY FOR NEURO-ONCOLOGY SCIENTIFIC MEETING
  • Place of Presentation: Scottsdale, USA
  • Int'l Joint Research
• [Presentation] WHO grade II/III 神経膠腫700例の大規模ゲノム解析から得られた遺伝学的予後予測因子 (2015)
  • Author(s): 青木恒介、鈴木啓道、中村英夫、松尾恵太郎、本村和也、大岡史治、椎名諭、山本高士、溝口昌弘、籾井泰朋、村垣善浩、眞田昌、宮野悟、若林俊彦、小川誠司、夏目敦至
  • Organizer: 第33回日本脳腫瘍学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2015-12-06
• [Presentation] Prognostic significance of genetic alterations from comprehensive analysis in lower-grade gliomas (2015)
  • Author(s): KOSUKE AOKI, Hiromichi Suzuki, Hideo Nakamura, Kazuya Motomura, Fumiharu Ohka, Masahiro Mizoguchi, Yasutomo Momii, Yoshihiro Muragaki, Reiko Watanabe, Ichiro Ito, Satoru Miyano, Toshihiko Wakabayashi, Seishi Ogawa, Atsushi Natsume.
  • Organizer: 20th ANNUAL SOCIETY FOR NEURO-ONCOLOGY SCIENTIFIC MEETING
  • Place of Presentation: San Antonio, TX, USA
  • Year and Date: 2015-11-19
  • Int'l Joint Research
• [Presentation] 低悪性度神経膠腫700例における大規模ゲノム解析と臨床、病理所見から得られた予後予測因子 (2015)
  • Author(s): 青木 恒介, 鈴木 啓道, 中村 英夫, 本村 和也, 大岡 史治, 椎名 諭, 山本 高士, 溝口 昌弘, 籾井 泰朋, 村垣 善浩, 眞田 昌, 宮野 悟, 若林 俊彦, 小川 誠司, 夏目 敦至
  • Organizer: 第74回日本脳神経外科学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-10-14
• [Presentation] Prognostic relevance of comprehensive genetic profiling in lower-grade gliomas (2015)
  • Author(s): Kosuke Aoki, Hiromichi Suzuki, Kenichi Chiba, Yuichi Shiraishi, Tatsuya Abe, Teppei Shimamura, Atsushi Niida, Masashi Sanada,Masashi Miyano, Toshihiko Wakabayashi, Atsushi Natsume, and Seishi Ogawa
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08