Cellular mechanisms underlying anisotropic bone matrix construction
| Project/Area Number |
15H06361
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural/Functional materials
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAKANO Takayoshi 大阪大学, 大学院工学研究科, 教授 (30243182)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 骨配向性 / 生体アパタイト結晶 / 細胞配列 / 細胞間相互作用 / オステオサイト / 骨芽細胞 / 破骨細胞 / 遺伝子 / アパタイト |
|---|
| Outline of Final Research Achievements |
Bone tissue anisotropy is determined by the osteoblast arrangement. In bone tissue, osteoblast behaviors are regulated by the mutual activities of other types of bone cells. Understanding the cell-cell communication is essential to reveal the molecular mechanisms underlying the anisotropic bone tissue formation. A novel coculture model was established to understand the intercellular communication between osteoblast, osteoclast, and osteocyte. We discovered the mechanosensing by osteocytes regulate the osteoblast arrangement. In addition, the crosstalk between osteoclasts and osteoblasts play key roles in anisotropic bone tissue construction.
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Report
(3 results)
Research Products
(72 results)
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[Presentation] 生体内類似異方性血管構造の構築2016
Author(s)
山崎 大介、小笹 良輔、松垣 あいら、中野 貴由
Organizer
第159回日本金属学会秋期講演大会
Place of Presentation
大阪大学豊中キャンパス（大阪府・豊中市）
Year and Date
2016-09-21
Related Report
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[Presentation] Mechanical strain-induced bone matrix alignment2015
Author(s)
Aira Matsugaki, Natsuko Fujiwara, Takayoshi Nakano
Organizer
The 24th International Symposium on Processing and Fabrication of Advanced Materials
Place of Presentation
Kansai University Senriyama Campus Centenary Memorial Hall
Year and Date
2015-12-20
Related Report
Invited
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