The role of 11be-ta-HSD1 in Dermatoporosis

Research Project

Project/Area Number	15H06375
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Dermatology
Research Institution	Osaka University
Principal Investigator	Saori Ochi 大阪大学, 医学系研究科, 助教 (00597495)
Project Period (FY)	2015-08-28 – 2017-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	11β-HSD1 / skin / mouse / cortisol / dermatoporosis / Dermatoporosis / 表皮 / コルチゾール / ステロイド / 皮膚萎縮 / 老化
Outline of Final Research Achievements	The mRNA expression of 11β-hydroxysteroid dehydrogenase 1(11β-HSD1)increased at 24 and 48 hours after steroid treatment. Otherwise,the mRNA expression of11β-HSD1 decreased at long time after steroid treatment. Aged mice or steroid treated-mice were epidermal atrophy and the expression of 11β-HSD1increased inkeratinocytes.