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The role of tumor-associated neutrophils in endometrial cancer displaying tumor-related leukocytosis.

Research Project

Project/Area Number 15H06378
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionOsaka University

Principal Investigator

Matsumoto Yuri  大阪大学, 医学部附属病院, 助教 (90756488)

Research Collaborator Kuroda Hiromasa  
Kozasa Katsumi  
Yokoi Eriko  
Komura Naoko  
Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords子宮体癌 / TRL / TAN / 浸潤・転移 / 前転移ニッチ / CD66b / G-CSF
Outline of Final Research Achievements

Objective: The aim of this study is to investigate the causative mechanism of poor prognosis in endometrial cancer patients displaying TRL (tumor-related leukocytosis), focusing on TAN (tumor-associated neutrophils).
Results and Conclusion: The TAN density of the patient`s endometrial cancer was significantly associated with pretreatment peripheral neutrophils and shorter progression-free-survival. Iv vitro and in vivo experiments revealed that TAN enhanced the invasive capacity and chemotactic activity of endometrial cancer. TAN was infiltrated in the premetastatic lungs and made premetastatic niche, expressing chemoattractant S100a8/9 that attracted the endometrial cancer cells of TRL model. These results indicate that TAN contribute to tumor cell metastases by premetastatic niche formation.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (11 results)

All 2017 2016 2015

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (3 results) Book (4 results)

  • [Journal Article] Impact of histological subtype on survival in patients with locally advanced cervical cancer that were treated with definitive radiotherapy: adenocarcinoma/adenosquamous carcinoma versus squamous cell carcinoma.2017

    • Author(s)
      Yokoi, E. Mabuchi, S. Takahashi, R. Matsumoto, Y. Kuroda, H. Kozasa, K. Kimura, T.
    • Journal Title

      J Gynecol Oncol

      Volume: 28(2) Issue: 2

    • DOI

      10.3802/jgo.2017.28.e19

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The prognosis of high-risk early-stage cervical cancer patients who did not receive standard postoperative concurrent chemoradiotherapy: a monoinstitutional study.2017

    • Author(s)
      Kuroda, H. Mabuchi, S. Matsumoto, Y. Kozasa, K. Sasano, T. Takahashi, R. Ueda, Y. Tomimatsu, T. Yoshino, K. Kimura, T.
    • Journal Title

      Eur J Gynaecol Oncol

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preclinical investigations of PM01183 (lurbinectedin) as a single agent or in combination with other anticancer agents for clear cell carcinoma of the ovary.2016

    • Author(s)
      Takahashi, R. Mabuchi, S. Kawano, M. Sasano, T. Matsumoto, Y. Kuroda, H. Kozasa, K. Hashimoto, K. Sawada, K. Kimura, T.
    • Journal Title

      PLoS ONE

      Volume: 17;11(3)

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic significance of systemic neutrophil and leukocyte alterations in surgically treated endometrial cancer patients: a monoinstitutional study.2015

    • Author(s)
      Takahashi R, Mabuchi S, Kawano M, Sasano T, Matsumoto Y, Kuroda H, Hisamatsu T, Kozasa K, Sawada K, Hamasaki T, Kimura T.
    • Journal Title

      Gynecol Oncol

      Volume: 137(1) Issue: 1 Pages: 112-8

    • DOI

      10.1016/j.ygyno.2015.02.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 骨髄由来免疫抑制細胞(MDSC)は子宮頸癌組織中の癌幹細胞を増加させる2016

    • Author(s)
      黒田浩正 馬淵誠士 小笹勝巳 笹野智之 髙橋良子 松本有里 橋本香映 澤田健二郎 木村正
    • Organizer
      第58回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      米子
    • Year and Date
      2016-07-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] The role of G-CSF-induced myeloid-derived suppressor cells (MDSC)in the induction of cancer stem-like cells in cervical cancer.2016

    • Author(s)
      Kuroda, H. Mabuchi, S. Kozasa, K. Sasano, T. Takahashi, R. Matsumoto, Y. Hashimoto, K. Sawada, K. Kimura, T.
    • Organizer
      第68回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 17β-estradiol promotes cervical cancer progression by stimulating the production of myeloid derived suppressor cells from hematopoietic stem cells.2016

    • Author(s)
      Kozasa, K. Mabuchi, S. Kuroda, H. Sasano, T. Takahashi, R. Matsumoto, Y. Hashimoto, K. Sawada, K. Kimura, T.
    • Organizer
      第68回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Book] Management of Metastatic and Recurrent Cervical Cancer.2016

    • Author(s)
      Mabuchi, S. Kawano, M. Takahashi, R. Kuroda, H.
    • Publisher
      Handbook of Gynecology, Springer
    • Related Report
      2016 Annual Research Report
  • [Book] Fertility-Sparing Treatment for Early-Stage Cervical Cancer.2016

    • Author(s)
      Kuroda, H. Mabuchi, S. Kozasa, K. Kimura, T.
    • Publisher
      Handbook of Gynecology, Springer
    • Related Report
      2016 Annual Research Report
  • [Book] Cervical Cancer: General Overview.2016

    • Author(s)
      Mabuchi, S. Kawano, M. Matsumoto, Y. Kimura, T.
    • Publisher
      Handbook of Gynecology, Springer
    • Related Report
      2016 Annual Research Report
  • [Book] Management of Early-Stage and Locally Advanced Cervical Cancer.2016

    • Author(s)
      Mabuchi, S. Kawano, M. Sasano, T. Kuroda, H.
    • Publisher
      Handbook of Gynecology, Springer
    • Related Report
      2016 Annual Research Report

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Published: 2015-08-26   Modified: 2018-03-22  

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