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Role of IFN-gamma in elimination of intracellularly invaded oral bacteria and disease progression.

Research Project

Project/Area Number 15H06382
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionOsaka University

Principal Investigator

Ohshima Jun  大阪大学, 歯学研究科, 助教 (30755450)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords微生物学 / 歯学 / 微生物 / 細菌 / 感染症 / 免疫学
Outline of Final Research Achievements

The purpose of this study was to investigate the binding molecule of Gbp, a kind of IFN-gamma-inducible GTPase, and to try to elucidate the regulatory mechanism of IFN-gamma-induced GTPases' function. In addition, we aimed to clarify the mechanism of progression and prolongation of periodontal disease by examining the relationship between host defense through IFN-gamma and oral bacteria invading into the host cells. As a result, we were able to identify RabGDI-alpha as a novel molecule that binds to Gbp2 and negatively regulates its function. Also, it was suggested that IFN-gamma is involved in elimination of intracellularly invaded oral bacteria and subsequent production of inflammatory cytokines and that P. gingivalis has an unknown mechanism to negatively control IFN-signaling.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report

Research Products

(7 results)

All 2015

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.2015

    • Author(s)
      Ohshima J, Sasai M, Liu J, Yamashita K, Ma JS, Lee Y, Bando H, Howard JC, Ebisu S, Hayashi M, Takeda K, Standley DM, Frickel EM, Yamamoto M.
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A.

      Volume: 112

    • DOI

      10.1073/pnas.1510031112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] mTOR Complex Signaling through the SEMA4A-Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells.2015

    • Author(s)
      Ito D, Nojima S*, Nishide M, Okuno T, Takamatsu H, Kang S, Kimura T, Yoshida Y, Morimoto K, Maeda Y, Hosokawa T, Toyofuku T, Ohshima J, Kamimura D, Yamamoto M, Murakami M, Morii E, Rakugi H, Isaka Y, Kumanogoh A*. (* correspondence)
    • Journal Title

      J Immunol

      Volume: 195 Pages: 934-43

    • DOI

      10.4049/jimmunol.1403038

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] p62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen.2015

    • Author(s)
      Lee Y, Sasai M, Ma JS, Sakaguchi N, Ohshima J, Bando H, Saitoh T, Akira S, Yamamoto M
    • Journal Title

      Cell Rep.

      Volume: 13 Pages: 223233-223233

    • DOI

      10.1016/j.celrep.2015.09.005

    • NAID

      120007001422

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.2015

    • Author(s)
      Sasai M, Ohshima J, Ma JS, Lee Y, Takeda K, Yamamoto M.
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] p62 plays a specific role in IFN-g-induced presentation of a Toxoplasma vacuolar antigen.2015

    • Author(s)
      Lee Y, Sasai M, Ma JS, Sakaguchi N, Ohshima J, Bando H, Saitoh T, Akira S, and Yamamoto M.
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6.2015

    • Author(s)
      Ma JS, Sasai M, Ohshima J, Lee Y, Bando H, Takeda K, and Yamamoto M.
    • Organizer
      Forum Cheju17
    • Place of Presentation
      Taniguchi Memorial Hall, Research Institute for Microbial Diseases, Osaka University(大阪府吹田市)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] p62 plays a specific role in IFN-g-induced presentation of a Toxoplasma vacuolar antigen.2015

    • Author(s)
      Lee Y, Sasai M, Ma JS, Sakaguchi N, Ohshima J, Bando H, Saitoh T, Akira S, and Yamamoto M.
    • Organizer
      Forum Cheju17
    • Place of Presentation
      Taniguchi Memorial Hall, Research Institute for Microbial Diseases, Osaka University(大阪府吹田市)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2015-08-26   Modified: 2018-03-22  

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