The relationship between salivary inflammatory cytokines and risk factors for atherosclerosis

• Project/Area Number: 15H06384
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Osaka University
• Principal Investigator: Kosaka Takayuki 大阪大学, 歯学部附属病院, 医員 (40755360)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 唾液 / 歯周病 / 動脈硬化 / 咀嚼能率 / 疫学 / 歯学 / 循環器・高血圧 / 衛生 / 老化

Outline of Final Research Achievements

This study assessed the relationship between oral health and general health in a Japanese urban population. Below results were found; 1. We got basic data for longitudinal analysis about the relationship between salivary inflammatory cytokines and arteriosclerotic disease. 2. Prevalence of periodontal bacteria with its total burden related to serum lipid profile. 3. The impact of factors influencing masticatory performance varied among different occlusal support areas. 4. We found several factors related to long term changes ofmasticatory performance.

Research Products

• [Journal Article] Relationship between metabolic syndrome and objective masticatory performance in a Japanese general population: the Suita study. (2017)
  • Author(s): Miki Kikui, Takahiro Ono, Yoshihiro Kokubo, Momoyo Kida, Takayuki Kosaka, Masaaki Yamamoto, Takashi Nokubi, Makoto Watanabe, Yoshinobu Maeda, Yoshihiro Miyamoto.
  • Journal Title: Journal of Dentistry Volume: 56 Pages: 53-57
  • DOI: 10.1016/j.jdent.2016.10.014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Relationship between Metabolic Syndrome Components and Periodontal Disease in a Japanese General Population: the Suita Study (2017)
  • Author(s): Miki Kikui, Yoshihiro Kokubo, Takahiro Ono, Momoyo Kida, Takayuki Kosaka, Masaaki Yamamoto, Makoto Watanabe, Yoshinobu Maeda, Yoshihiro Miyamoto.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 5 Pages: 495-507
  • DOI: 10.5551/jat.33761
  • NAID: 130005631699
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A multifactorial model of masticatory performance: the Suita study (2016)
  • Author(s): Kosaka T, Ono T, Kida M, Kikui M, Yamamoto M, Yasui S, Nokubi T, Maeda Y, Kokubo Y, Watanabe M, Miyamoto Y
  • Journal Title: J Oral Rehabil Volume: 43 Issue: 5 Pages: 340-347
  • DOI: 10.1111/joor.12371
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 半量グミゼリーによる咀嚼能率スコア法の開発 (2016)
  • Author(s): 小野高裕，安井栄，金田恒，菊池さつき，來田百代、高阪貴之，菊井美希，前田芳信，野首孝祠
  • Journal Title: 日本咀嚼学会雑誌 Volume: 26 Pages: 9-13
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Does the utilization of dental services associate with masticatory performance in a Japanese urban population?: the Suita study (2015)
  • Author(s): Miki Kikui, Takahiro Ono, Momoyo Kida, Takayuki Kosaka, Masaaki Yamamoto, Yoko Yoshimuta, Sakae Yasui, Takashi Nokubi, Yoshinobu Maeda, Yoshihiro Kokubo, Makoto Watanabe, Yoshihiro Miyamoto
  • Journal Title: Clinical and Experimental Dental Research Volume: 1 Issue: 2 Pages: 57-62
  • DOI: 10.1002/cre2.10
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 都市部一般住民における咀嚼能率の縦断的推移－吹田研究－ (2016)
  • Author(s): 高阪貴之，小野高裕，來田百代，菊井美希，橋本栄，藤井克則，山本雅章，前田芳信，金田恒，小久保喜弘，野首孝祠
  • Organizer: 日本咀嚼学会第27回学術大会
  • Place of Presentation: 広島大学霞キャンパス広仁会館（広島県広島市）
  • Year and Date: 2016-11-05
• [Presentation] 歯数の自己認識に見るオーラルリテラシーと咀嚼能率との関連 －吹田研究－ (2016)
  • Author(s): 橋本 栄，小野高裕，來田百代，高阪貴之，菊井美希，藤井克則，山本雅章，野首孝祠，小久保喜弘，前田芳信
  • Organizer: 日本咀嚼学会第27回学術大会
  • Place of Presentation: 広島大学霞キャンパス広仁会館（広島県広島市）
  • Year and Date: 2016-11-05
• [Presentation] 咀嚼能力の低下および歯周病とメタボリックシンドロームとの関連－吹田研究－ (2015)
  • Author(s): 菊井美希，小野高裕，山本雅章，來田百代，高阪貴之，橋本栄，藤井克則，野首孝祠，小久保喜弘，前田芳信，宮本恵宏，渡邊至
  • Organizer: 第26回日本咀嚼学会学術大会
  • Place of Presentation: 神奈川県，横浜市，鶴見大学会館
  • Year and Date: 2015-09-26
• [Presentation] 口腔腫瘍術後患者の咀嚼機能回復に関連する因子の検討 (2015)
  • Author(s): 山本雅章，城下尚子，來田百代，高阪貴之，前田芳信
  • Organizer: 第26回日本咀嚼学会学術大会
  • Place of Presentation: 神奈川県，横浜市，鶴見大学会館
  • Year and Date: 2015-09-26