| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In this study, we generated B cell-specific CD40 conditional knockout mice (B cell CD40cKO) to analyze the influence of CD40 on B cells on bone metabolism. B cell CD40cKO mice were smaller compared to control mice. The structure of the trabecular bone of femurs of B cell CD40cKO mice was destroyed. Furthermore, bone mineral density and bone volume were decreased in B cell CD40cKO mice, compared to control mice. Thus, CD40 on B cells is important for maintenance of bone homeostasis. We are currently analyzing the roles of CD40 on B cells under an inflamed condition using periodontitis-induced B cell CD40cKO mice.
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