Analysis of bone metabolism in B cell-specific CD40 conditional knockoout mice
| Project/Area Number |
15H06391
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontology
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| Research Institution | Osaka University |
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Principal Investigator |
FUJIHARA CHIHARU 大阪大学, 歯学研究科, 特任助教(常勤) (00755358)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | CD40 / B細胞 / 骨代謝 / コンディショナルノックアウトマウス / 歯周炎 / 歯周病 / 免疫 |
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| Outline of Final Research Achievements |
In this study, we generated B cell-specific CD40 conditional knockout mice (B cell CD40cKO) to analyze the influence of CD40 on B cells on bone metabolism. B cell CD40cKO mice were smaller compared to control mice. The structure of the trabecular bone of femurs of B cell CD40cKO mice was destroyed. Furthermore, bone mineral density and bone volume were decreased in B cell CD40cKO mice, compared to control mice. Thus, CD40 on B cells is important for maintenance of bone homeostasis. We are currently analyzing the roles of CD40 on B cells under an inflamed condition using periodontitis-induced B cell CD40cKO mice.
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Report
(3 results)
Research Products
(7 results)
