| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
One of the central questions in the development of the central nervous system is to understand the molecular mechanisms leading to the complex and precise pattern formation of the neural tube. We have been focusing on one of the extracellular signal molecules Sonic Hedgehog (shh), and have attempted to isolate the intracellular factors that regulate the dynamic signal activity in the neural progenitor cells. Consequently we revealed that the negative feedback of the Shh signal activity is essential for the precise pattern formation, and this negative feedback is regulated by a novel G-protein coupled receptor.
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