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Elucidation of the role of TFG in glucose and lipid metabolism in pancreas, liver and adipose tissue

Research Project

Project/Area Number 15H06427
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionHiroshima University

Principal Investigator

Yamamotoya Takeshi  広島大学, 医歯薬保健学研究院(医), 助教 (50760013)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords糖尿病 / インスリン分泌 / TFG / 脂質代謝 / 細胞内小胞輸送
Outline of Final Research Achievements

To elucidate the role of TFG in insulin secretion, we generated pancreatic β-cell specific TFG knockout mice (βTFG KO) and analyzed the phenotype. βTFG KO displayed marked hyperglycemia with impaired insulin secretion on glucose tolerance test. Impairment of both β-cell mass and function was suggested by smaller insulin-positive area in the immunohistochemical analysis of the pancreas and reduced insulin secretion on glucose stimulation in isolated islets. Electron microscopic observation and microarray gene expression analysis revealed smaller insulin crystal diameters, mild ER stress and downregulation of Nrf2 and its downstream genes as possible underlying mechanisms for the impaired β-cell mass and function in βTFG KO.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (5 results)

All 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Reduced SHARPIN and LUBAC formation may contribute to CCl<sub>4</sub> - Or acetaminophen-induced liver cirrhosis in mice2017

    • Author(s)
      Yamamotoya T, Nakatsu Y, Matsunaga Y, Fukushima T, Yamazaki H, Kaneko S, Fujishiro M, Kikuchi T, Kushiyama A, Tokunaga F, Asano T, and Sakoda H.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 18 Issue: 2 Pages: 326-326

    • DOI

      10.3390/ijms18020326

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis.2016

    • Author(s)
      Kushiyama A, Nakatsu Y, Matsunaga Y, Yamamotoya T, Mori K, Ueda K, Inoue Y, Sakoda H, Fujishiro M, Ono H, Asano T.
    • Journal Title

      Mediators Inflamm.

      Volume: 2016 Pages: 8603164-8603164

    • DOI

      10.1155/2016/8603164

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations.2016

    • Author(s)
      Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, Mori K, Sakoda H, Fujishiro M, Ono H, Kushiyama A, Asano T.
    • Journal Title

      Int J Mol Sci.

      Volume: 17 (9) Issue: 9 Pages: 1495-1495

    • DOI

      10.3390/ijms17091495

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 膵β細胞におけるTrk-fused gene (TFG) の役割2016

    • Author(s)
      山本屋 武、中津 祐介、松永 泰花、櫛山 暁史、石原 寿光、浅野 知一郎
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] Trk-fused gene (TFG) の膵β細胞における役割の解明2016

    • Author(s)
      山本屋 武、中津 祐介、 迫田 秀之、藤城 緑、山崎 広貴、菊池 貴子、櫛山 暁史、浅野 知一郎
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      京都
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report

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Published: 2015-08-26   Modified: 2018-03-22  

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