| Project/Area Number |
15H06433
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
Oue Kana 広島大学, 病院(歯), 歯科診療医 (60760329)
|
|---|
| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 褐色脂肪細胞 / エネルギー代謝 / UCP1 / 肥満 |
|---|
| Outline of Final Research Achievements |
Phospholipase C-related catalytically inactive protein (PRIP) was first identified as an inositol 1,4,5-trisphosphate-binding protein. In this study, I examined the mechanism of PRIP-mediated energy consumption by analysing PRIP knockout (Prip-KO) mice. Prip-KO mice showed higher ability to consume fatty acids as an energy source and higher activity in non-shivering thermogenesis in brown adipocytes than wild-type mice. Energy consumption in Prip-KO beige adipocytes, which are differentiated from subcutaneous white adipocytes in response to cold exposure, was also upregulated. Collectively, these results indicate that PRIP is a new modulator for regulating the systemic energy expenditure. Hence, this increased understanding of non-shivering thermogenic mechanisms via PRIP offers important insights for the treatment and control of obesity.
|
