Generation of odontogenic tumor specific iPSCs in virus integration-, feeder-, and serum- free defined culture and their use for disease model study
| Project/Area Number |
15H06435
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
Hamada Atsuko 広島大学, 病院(歯), 歯科診療医 (30760318)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯原性腫瘍iPSC / 歯原性腫瘍由来iPSC / インテグレーションフリー / 無血清培養系 |
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| Outline of Final Research Achievements |
We succeeded to establish iPS cells from odontogenic tumor in integration-, serum-, feeder-free condition. Though pathogenic mechanism of odontogenic tumor is unknown, neural crest cells were considered as one of the origins of odontogenic tumor. In order to establish a disease model, we examined how to induce iPSC into neural crest cells in complete serum free condition. We believe that our iPSC derived from odontogenic tumor will contribute to elucidation of the pathogenesis of odontogenic tumor and elucidation of onset mechanism.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] Generation of cleidocranial dysplasia-specific human induced pluripotent stem cells in completely serum-, feeder-, and integration-free culture.2015
Author(s)
Yamasaki S, Hamada A, Akagi E, Nakatao H, Ohtaka M, Nishimura K, Nakanishi M, Toratani S, Okamoto T.
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Journal Title
In Vitro Cell Dev Biol Anim.
Volume: 52
Issue: 2
Pages: 252-264
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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