Application to development of the barrier membrane immobilized amelogenin new peptide and bone tissue regeneration

Research Project

Project/Area Number	15H06436
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Orthodontics/Pediatric dentistry
Research Institution	Hiroshima University
Principal Investigator	AWADA TETSUYA 広島大学, 病院(歯), 歯科診療医 (90758179)
Project Period (FY)	2015-08-28 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	アメロゲニン / ペプチド / バリアメンブレン / 骨再生 / 生体材料 / 固定 / メンブレン
Outline of Final Research Achievements	The present study revealed that a new amelogenin peptide affects the metabolism of MC3T3-E1 and MSCs. In addition, amgCP activated ERK1/2 through LAMP1 receptor, and it was suggested that amgCP had an influence on the cell proliferation of MSCs. Furthermore, it was revealed that the metabolism of MSCs were influenced by amgCP immobilization as is the case with addition. The authors suggest a possible barrier membrane immobilized amelogenin new peptide application for bone tissue regenerative procedures.

Report

(3 results)