The roll of rapid-phase parathyroid hormone secretion in chronic kidney disease-mineral and bone disorder

• Project/Area Number: 15H06442
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: The University of Tokushima
• Principal Investigator: MASUDA Masashi 徳島大学, 大学院医歯薬学研究部(医学系), 助教 (50754488)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 慢性腎臓病 / PTH / 栄養学

Outline of Final Research Achievements

Although plasma parathyroid hormone (PTH) and phosphorus levels were significantly increased by the administration of phosphate (40 mg) into the stomach, sympathetic and parasympathetic cannot inhibit rapid-phase PTH secretion. Next, the rapid-phase PTH secretion-induced by the administration of phosphate into the stomach was abolished by phosphonoformic acid (PFA) which suppresses the absorption of phosphate in small intestine. Although the administration of phosphate into the stomach decreased the protein expression of the type II sodium-dependent phosphate co-transporter Npt2a, capsaicin treatment which inhibits vagal afferent specific blocked the effect. Together, these results suggest that the rapid-phase PTH secretion affects signaling in the central nervous system through vagal afferent such as the phosphate sensing in small intestine, resulting in the expression of Npt2a protein in kidney.

Research Products

• [Presentation] 高リン食はマクロファージを活性化させ大腸炎を悪化させる (2017)
  • Author(s): 杉原康平、増田真志、中尾真理、Maerjianghan Abuduli、織田奈央子、山本浩範、武田英二、竹谷豊
  • Organizer: 第20回日本病態栄養学会年次学術集会
  • Place of Presentation: 国立京都国際会館（京都府・京都市）
  • Year and Date: 2017-01-13
• [Presentation] 食餌中の糖・脂肪の組成比率が腸管のリン吸収に及ぼす影響 (2017)
  • Author(s): 川本桂祐、佐久間理英、田中更沙、増田真志、中尾真理、新井田裕樹、伊藤美紀子、竹谷豊、新井英一
  • Organizer: 第20回日本病態栄養学会年次学術集会
  • Place of Presentation: 国立京都国際会館（京都府・京都市）
  • Year and Date: 2017-01-13
• [Presentation] 慢性腎臓病に伴う脂質代謝異常がProtein Energy Wastingに与える影響 (2016)
  • Author(s): 新井田裕樹、増田真志、吉澤和香、奥村仙示、竹谷豊
  • Organizer: 第49回日本栄養・食糧学会 中国・四国支部大会
  • Place of Presentation: 徳島大学蔵本キャンパス（徳島県・徳島市）
  • Year and Date: 2016-11-12
• [Presentation] 飽和脂肪酸と血管石灰化 (2016)
  • Author(s): 増田真志、宮崎淳
  • Organizer: 日本脂質栄養学会第25回大会
  • Place of Presentation: 秋田市にぎわい交流館AU（秋田県・秋田市）
  • Year and Date: 2016-09-16
  • Invited
• [Presentation] High phosphorus induces the lipolysis through endoplasmic reticurum stress. (2016)
  • Author(s): Yukiko Imi, Masashi Masuda, Maerjianghan Abuduli, Norie Yabiki, Hisami Yamanaka-Okumura, Makoto Miyazaki, Yutaka Taketani
  • Organizer: Kern Lipid Conference 2016
  • Place of Presentation: Colorado at the Vail Marriott Mountain Resort (Vail, USA)
  • Year and Date: 2016-08-08
  • Int'l Joint Research
• [Presentation] 高脂肪食が高リン食摂取時のミネラル代謝調節機に及ぼす影響 (2016)
  • Author(s): 矢引紀江、伊美友紀子、Maerjianghan Abuduli、増田真志、奥村仙示、山本浩範、武田英二、竹谷豊
  • Organizer: 日本ビタミン学会第68回大会
  • Place of Presentation: 富山国際会議場（富山県・富山市）
  • Year and Date: 2016-06-17
• [Presentation] Regulation of α-Klotho Expression by Dietary Phosphate During Growth Periods (2015)
  • Author(s): Shiori Fukuda, Hironori Yamamoto, Masashi Masuda, Mari Nakao, Yutaka Taketani
  • Organizer: American Society of Nephrology
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2015-11-03
  • Int'l Joint Research