Volatile anesthetic and GLP-1 induced cardiac protection synergism is dependent on the activation of autophagy.
| Project/Area Number |
15H06448
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KASAI Asuka 徳島大学, 病院, 特任助教 (90756892)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 吸入麻酔薬 / イソフルラン / オートファジー / 心筋保護 / 虚血再灌流障害 / GLP-1 / インクレチン / 心筋保護作用 / プレコンディショニング |
|---|
| Outline of Final Research Achievements |
We confirmed that volatile anesthetic-induced and GLP-1-induced cardiac preconditioning protects against ischemia-reperfusion injury in mice. Additionally, our results show that volatile anesthetic and GLP-1 induced cardiac protection synergism is dependent on the activation of autophagy.
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Report
(3 results)
Research Products
(7 results)
