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Development of non-invasive MRI assessment for chronic thromboembolic pulmonary hypertension

Research Project

Project/Area Number 15H06478
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKyushu University

Principal Investigator

Yamasaki Yuzo  九州大学, 大学病院, 医員 (00643347)

Research Collaborator Nagao Michinobu  東京女子医科大学, 画像診断学核医学講座, 准教授
Abe Kohtaro  九州大学, 大学院医学研究院循環機内科, 助教
Hosokawa Kazuya  九州大学, 大学病院, 医員
Horimoto Koshin  九州大学, 大学病院, 医員
Kamitani Takeshi  九州大学, 大学院医学研究院臨床放射線科, 助教
Sagiyama Koji  九州大学, 大学院医学研究院臨床放射線科, 助教
Yabuuchi Hidetake  九州大学, 大学院医学研究院保健学科, 教授
Honda Hiroshi  九州大学, 大学院医学研究院臨床放射線科, 教授
Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsMRI / 肺高血圧 / 肺動脈バルーン形成術 / 心室間同期不全 / 放射線 / 循環器
Outline of Final Research Achievements

Cardiac function and interventricular dyssynchrony in chronic thromboembolic pulmonary hypertension were evaluated before and after balloon pulmonary angioplasty (BPA) using cardiac MRI, and compared to the parameters derived from cardiac catheterization, laboratory test, and 6-minute walk test. The decrease in right ventricular volume was correlated with the decrease in pulmonary artery pressure. The possibility of MRI for non-invasive assessment of pulmonary hypertension was shown. The improvement of interventricular dyssynchrony was correlated with the increase of stroke volume. Not only right ventricle but also left ventricle were improved by BPA and the mechanism was revealed.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (8 results)

All 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Balloon Pulmonary Angioplasty Improves Interventricular Dyssynchrony in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension: A Cardiac MR Imaging Study2017

    • Author(s)
      Yuzo Yamasaki et al.
    • Journal Title

      International Journal of Cardiovascular Imaging

      Volume: 33 Issue: 2 Pages: 229-239

    • DOI

      10.1007/s10554-016-0985-y

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] nergy efficiency and pulmonary artery flow after balloon pulmonary angioplasty for inoperable, chronic thromboembolic pulmonary hypertension: Analysis by phase-contrast MRI2017

    • Author(s)
      Michinobu Nagao, Yuzo Yamasaki et al.
    • Journal Title

      European Journal of Radiology

      Volume: 87 Pages: 99-104

    • DOI

      10.1016/j.ejrad.2016.12.015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 慢性血栓塞栓性肺高血圧症患者における肺動脈血流を評価するために検証された三次元位相コントラスト磁気共鳴法(Three-dimensional phase contrast magnetic resonance imaging validated to assess pulmonary artery flow in patients with chronic thromboembolic pulmonary hypertension)2017

    • Author(s)
      Masteru Kawakubo, Hiroshi Akamine, Yuzo Yamasaki et al.
    • Journal Title

      Radiological Physics and Technology

      Volume: 10 Issue: 2 Pages: 249

    • DOI

      10.1007/s12194-016-0383-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] 心房中隔欠損におけるPhase contrast MRIを用いたQp/Qs評価:息止めの違いによる比較2017

    • Author(s)
      山崎誘三他
    • Organizer
      第84回心臓血管放射線研究会
    • Place of Presentation
      三重県津市
    • Year and Date
      2017-01-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Quantitative MR Imaging in Pulmonary Hypertension: How to Evaluate the Hemodynamics and Treatment Effect2016

    • Author(s)
      Yuzo Yamasaki et al.
    • Organizer
      Radiological Society of North America 2016
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2016-11-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cardiovascular CT and MR imaging in adult congenital heart disease: A practical approach to the current state of the art2016

    • Author(s)
      Yuzo Yamasaki et al.
    • Organizer
      Radiological Society of North America 2016
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2016-11-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 慢性血栓塞栓性肺高血圧へのバルーン肺動脈形成術は心室間同期不全、左室充満障害を改善する: MRIでの評価2016

    • Author(s)
      山崎誘三、他
    • Organizer
      第26回心血管画像動態学会
    • Place of Presentation
      東京
    • Year and Date
      2016-01-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Energy Efficiency After Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension: Assessment by Phase-contrast MRI2016

    • Author(s)
      長尾充展、山崎誘三、他
    • Organizer
      第1回アジア・オセアニア呼吸機能イメージングワークショップ/第8回呼吸機能イメージング研究会学術集会
    • Place of Presentation
      兵庫県
    • Year and Date
      2016-01-29
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2015-08-26   Modified: 2018-03-22  

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