| Project/Area Number |
15H06490
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | インプラント / 治癒 / スタチン / 歯学 |
|---|
| Outline of Final Research Achievements |
An adequate volume of alveolar bone is one of the most important factors determining a favorable outcome in the field of dental implantology. Statins have been widely used for the clinical treatment of hyperlipidemia. In addition, it was reported that it promoted bone formation. In this study, we examine the effect of fluvastatin on promotion of bone-implant contact (BIC) after implant treatment.Right maxillary first molars were extracted from rats and replaced with experimental implants.Then one of the following was immediately injected, as a s ingle dose, into the gingivobuccal fold: control (no administration), PLGA microspheres without a statin (active control), or PLGA microspheres containing 0.5 (FS-PL 0.5) or 1.0 mg/kg (FS-PL 1.0) of fluvastatin. At days 28 after injection, BIC were evaluated. BIC was significant promoted at FS-PL 0.5 and 1.0. A single dose of topically administered fluvastatin-impregnated PLGA microspheres promoted BIC at implant treatment.
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