| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Sphingosine-1-phosphate (S1P) is known as the signaling sphingolipid and the bioactive lipid mediator that also plays crucial roles in osteogenic differentiation. In the present study, we investigated the involvement of Wnt signaling on S1P-induced osteogenic differentiation of MSC. We particularly paid attention to β-catenin-dependent and -independent Wnt signaling pathways because both signaling pathways regulate bone formation.
We found that S1P up-regulated Wnt5a expression, leading to the induction of LRP5/6 expression, resulting in the increase of β-catenin-dependent Wnt signaling, and thereby promoting MSC differentiation into osteoblast.
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