Role of lipid mediator on periodontal tissue regeneration through Wnt5a expression.
| Project/Area Number |
15H06493
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Periodontology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 間葉系幹細胞分化 / スフィンゴシン-1-リン酸 / Wntシグナル伝達経路 / 歯周組織再生 |
|---|
| Outline of Final Research Achievements |
Sphingosine-1-phosphate (S1P) is known as the signaling sphingolipid and the bioactive lipid mediator that also plays crucial roles in osteogenic differentiation. In the present study, we investigated the involvement of Wnt signaling on S1P-induced osteogenic differentiation of MSC. We particularly paid attention to β-catenin-dependent and -independent Wnt signaling pathways because both signaling pathways regulate bone formation.
We found that S1P up-regulated Wnt5a expression, leading to the induction of LRP5/6 expression, resulting in the increase of β-catenin-dependent Wnt signaling, and thereby promoting MSC differentiation into osteoblast.
|
Report
(3 results)
Research Products
(5 results)
