A study for establishment of assessments by registered nurse for sleep disordered breathing to prevent cardiovascular diseases in patients with Down syndrome

• Project/Area Number: 15H06494
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Clinical nursing
• Research Institution: Kyushu University
• Principal Investigator: Sawatari Hiroyuki 九州大学, 総合研究博物館, 専門研究員 (30757034)
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 循環器 / 血管内皮 / 睡眠呼吸障害 / 低酸素血症 / 看護学 / ダウン症 / 血管内皮機能 / 看護

Outline of Final Research Achievements

This study was conducted as the first study for management of patients with down syndrome and cardiovascular diseases to prevent cardiac events, and investigated the relationship between arterial endothelial function and sleep disordered breathing in patients with chronic heart failure. This study showed that the endothelial function related to accumulated hypoxia in the patients with chronic heart failure. The assessment, focus on hypoxia during sleep, by registered nurse might have a pivotal role for prevention of cardiac events not only in patients with chronic heart failure but also in patients with down syndrome and cardiovascular diseases.

Research Products

• [Journal Article] A Nationwide, Cross-sectional Survey on Unusual Sleep Postures and Sleep-disordered Breathing-related Symptoms in People with Down Syndrome (2017)
  • Author(s): Hiromi Kuroda, Hiroyuki Sawatari, Shin-ichi Ando, Tomoko Ohkusa, Anita Rahmawati, Junji Ono, Mari Nishizaka, Nobuko Hashiguchi, Fumio Matsuoka, Akiko Chishaki.
  • Journal Title: Journal of Intellectual Disability Research Volume: 印刷中 Issue: 7 Pages: 656-667
  • DOI: 10.1111/jir.12379
  • Peer Reviewed / Open Access
• [Journal Article] The epidemiology of sleep disordered breathing and hypertension in various populations. (2016)
  • Author(s): Hiroyuki Sawatari, Akiko Chishaki , Shin-ich Ando
  • Journal Title: Current Hypertension Review Volume: 12 (1) Issue: 1 Pages: 12-17
  • DOI: 10.2174/1573402112666160114093307
  • Peer Reviewed
• [Presentation] The accumulated hypoxem ia during sleep independently predicted yascular endothelial dysfunction in patients w ith chronic heart failure (2016)
  • Author(s): Hiroyuki Sawatari, Shin-ichi Ando, Mari Nisizaka, Mami Miyazono, Shujiro Inoue, Masao Takemoto, Takafumi Sakamoto, Tomotake Tokunou, Chie Magota, Sakiko Handa, Unpei Yamamoto, Tomoko Ohkusa, Akiko Suyama Chishaki.
  • Organizer: SLEEP
  • Place of Presentation: Denver, USA
  • Year and Date: 2016-06-11
  • Int'l Joint Research
• [Presentation] Accumulated Hypoxemia by SDB Related to Vascular Endothelial Dysfunction Even in Patients with Heart Failure (2016)
  • Author(s): Hiroyuki Sawatari, Shin-ichi Ando, Mari Nishizaka, Mami Miyazono, Shujiro Inoue, Masao Takemoto, Takafumi Sakamoto, Tomotake Tokunou, Chie Magota, Sakiko Handa, Umpei Yamamoto, Tomoko Ohkusa, Akiko Chishaki.
  • Organizer: Cardio Sleep
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2016-04-29
  • Int'l Joint Research
• [Presentation] Accumulated Hypoxemia by SDB Related to Vascular Endothelial Dysfunction Even in Patients with Heart Failure (2016)
  • Author(s): Hiroyuki Sawatari, Shin-ichi Ando, Mari Nishizaka, Mami Miyazono, Shujiro Inoue, Masao Takemoto, Takafumi Sakamoto, Tomotake Tokunou, Chie Magota, Sakiko Handa , Umpei Yamamoto, Tomoko Ohkusa, Akiko Chishaki
  • Organizer: Cardiosleep
  • Place of Presentation: Prague-Czech Republic
  • Year and Date: 2016-04-29
  • Int'l Joint Research
• [Presentation] Accumulated Hypoxemia due to Sleep Disordered Breathing More Related to Arterial Endothelial Dysfunction than Apnea-Hypopnea Index in Heart Failure Patients (2016)
  • Author(s): Hiroyuki Sawatari, Shin-ichi Ando, Mari Nishizaka, Mami Miyazono, Shujiro Inoue, Masao Takemoto, Takafumi Sakamoto, Tomotake Tokunou, Chie Magota, Sakiko Handa, Umpei Yamamoto, Tomoko Ohkusa, Akiko Chishaki
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城
  • Year and Date: 2016-03-18
• [Presentation] The Calculated Hypoxemia Index Significantly Predicted Vascular Endothelial Dysfunction in Patients with Heart Failure (2015)
  • Author(s): Hiroyuki Sawatari, Shin-ichi Ando, Mari Nishizaka, Mami Miyazono, Shujiro Inoue, Takafumi Sakamoto, Tomotake Tokunou, Akiko Chishaki
  • Organizer: Bio4app
  • Place of Presentation: Fukuoka-Japan
  • Year and Date: 2015-12-09
  • Int'l Joint Research
• [Presentation] The Accumulated Hypoxemia by Sleep Disordered Breathing Affects Vascular Endothelial Function Especially in the Patients with Ischemic Cardiac Failure (2015)
  • Author(s): Hiroyuki Sawatari, Shin-ichi Ando, Mari Nishizaka, Mami Miyazono, Shujiro Inoue, Takafumi Sakamoto, Tomotake Tokunou, Hiroaki Chishaki, Akiko Chishaki
  • Organizer: The 11th International Congress on Coronary Artery Disease
  • Place of Presentation: Firenze-Italy
  • Year and Date: 2015-11-29
  • Int'l Joint Research