| Project/Area Number |
15H06496
|
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Collagenous pathology/Allergology
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|---|
| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ペリオスチン / アレルギー / シグナル伝達 / 炎症 / アレルギー・ぜんそく / シグナル伝達ル伝達 / アトピー性皮膚炎 |
|---|
| Outline of Final Research Achievements |
Although it is known that periostin, a matricellular protein, plays a critical role in allergic inflammation, the detailed mechanism of signaling mechanism of periostin is unclear. In this study, we aimed to elucidate the signaling mechanism of periostin in the inflammatory signaling. We obtained preliminary evidence that specific isoform of periostin has the ability of NF-kB activation. We identified a candidate of the periostin receptor on the cell surface. Moreover, we also found the inducible factor downstream of the periostin signaling pathway.
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