| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Intracellular calcium plays an important role in cancer progression and metastasis. In this study, we investigated the role of transient receptor potential (TRP) channels, Ca2+-permeable nonselective cation channels, in oral squamous cell carcinoma (OSCC).HSC4, well-differentiated OSCC cell line, highly expressed functional TRPV4 channel. Knockdown of TRPV4 showed the change of localization of the adherens junction molecules. Furthermore, TRPV4 silencing induced enhancement of migration in HSC4. Additionally, TRPV4 activation led cell death presumably via JNK/p38 pathway.
These results suggest that TRPV4 wound be a novel therapeutic target for oral cancer therapy.
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