| Project/Area Number |
15H06505
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NEMOTO Takayuki K. 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (90164665)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯科 / 歯周病原細菌 / ポルフィロモナス属 / ジペプチジルペプチダーゼ / Porphyromonas属 / P. endodontalis |
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| Outline of Final Research Achievements |
The dental caries in infants progresses rapidly and pulpally, after it penetrates the protective enamel down to the dentin, in comparison with the same in adults. A periapical abscess occurs as the common clinical feature, when inflammation spreads to the pulp and the apical area of a deciduous tooth or an immature permanent tooth, secondary to the tooth decay. Porphyromonas endodontalis is the bacterium isolated from endodontic infections such as the root apex and the infected root canal involved with strong clinical manifestations.
Our study revealed that P. endodontalis and Porphyromonas gingivalis have dipeptidyl-peptidase (DPP)which decomposes extracellular oligopeptide into dipeptide as energy source. We found that each bacterium of these showed different activities of DPP.
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