Research Project
Grant-in-Aid for Research Activity Start-up
Recently we found that beta-lactam antibiotics is inactivated by reaction with thiol compounds such as cysteine. On the basis of LC-MSMS and NMR analysis, it was shown that beta-lactam antibiotics and cysteine formed one to one adduct. E.coli fliY mutant, which is loss of cysteine/cystien shuttle system, showed high-sensitive to beta-lactam antibiotics and produced less cysteine-beta lactic antibiotics adduct compared with wild type strain. These results suggest that bacterial cysteine might contribute to antibiotics resistance via formation of cysteine-beta-lactam antibiotics adduct in periplasmic space.
All 2019 2017 2016 2015 Other
All Journal Article (7 results) (of which Int'l Joint Research: 6 results, Peer Reviewed: 6 results, Acknowledgement Compliant: 5 results, Open Access: 5 results) Presentation (7 results) Remarks (2 results)
細胞工学
Volume: 34 Pages: 92-395
Free Radic Biol Med
Volume: 106 Pages: 69-79
10.1016/j.freeradbiomed.2017.02.023
Chem Lett
Volume: 46 Issue: 4 Pages: 594-596
10.1246/cl.161198
130005549076
Biological and Pharmaceutical Bulletin
Volume: 40 Issue: 3 Pages: 365-374
10.1248/bpb.b16-00880
130005398514
Biochem Biophys Res Commun
Volume: 480 Issue: 2 Pages: 180-186
10.1016/j.bbrc.2016.10.022
Biochemistry
Volume: 55 Issue: 5 Pages: 751-761
10.1021/acs.biochem.5b00774
Arch. Biochem. Biophys.
Volume: 588 Pages: 15-24
10.1016/j.abb.2015.10.016
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