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Epidemiological and molecular analysis of decreased susceptibility to fluoroquinolone in Haemophilus influenzae

Research Project

Project/Area Number 15H06521
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Bacteriology (including mycology)
Research InstitutionSapporo Medical University

Principal Investigator

SATO TOYOTAKA  札幌医科大学, 医学部, 助教 (30756474)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsフルオロキノロン耐性 / インフルエンザ菌
Outline of Final Research Achievements

Haemophilus influenzae is present as a commensal organism in upper respiratory tract and cause respiratory tract infections. Fluoroquinolone is one of the potent antimicrobial agent for the treatment. Although detail mechanical analysis of fluoroquinolone resistant development is important for prevent the emergence and spreading of fluoroquinolone resistant H. influenzae, that mechanism has been unclear. In this study, all H. influenzae clinical isolates exhibited susceptible to fluoroquinolone. However, 2 of the 64 (3.1%) isolates decreased susceptibility to fluoroquinolone with an amino acid substitution in QRDR. in vitro fluoroquinolone exposer experiment showed that 55.2% of H. influenzae clinical isolates decreased fluoroquinolone susceptibility and 34.4% was developed fluoroquinolone resistance. We also observed the significant association between decreased susceptibility to fluoroquinolone and ampicillin resistance.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (9 results)

All 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (6 results)

  • [Journal Article] Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone- Resistant Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4- ST131-H30R and O1-ST6482017

    • Author(s)
      Sato T, Suzuki Y, Shiraishi T, Honda H, Shinagawa M, Yamamoto S, Ogasawara N, Takahashi H, Takahashi S, Tamura Y, Yokota SI
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 61 Issue: 2

    • DOI

      10.1128/aac.01654-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mechanism of Reduced Susceptibility to Fosfomycin in Escherichia coli Clinical Isolates2017

    • Author(s)
      Ohkoshi Y, Sato T, Suzuki Y, Yamamoto S, Shiraishi T, Ogasawara N, Yokota SI
    • Journal Title

      BioMed Research International

      Volume: Article ID 5470241 Pages: 5470241-5470241

    • DOI

      10.1155/2017/5470241

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Pathogenic Lineage of mcr-Negative Colistin-Resistant Escherichia coli, Japan, 2008-20152016

    • Author(s)
      Sato T, Fukuda A, Suzuki Y, Shiraishi T, Honda H, Shinagawa M, Yamamoto S, Ogasawara N, Usui M,Takahashi H, Takahashi S, Tamura Y, Yokota S
    • Journal Title

      Emerg. Infec. Dis

      Volume: 22 Issue: 12 Pages: 2223-2224

    • DOI

      10.3201/eid2212.161117

    • NAID

      120006666538

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Haemophilus influenzaeのキノロン系抗菌薬耐性獲得機序についての検討2017

    • Author(s)
      本田宏幸、佐藤豊孝、高橋弘毅、横田伸一
    • Organizer
      第91回日本感染症学会総会・第65回日本化学療法学会学術集会合同学会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2017-04-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大腸菌臨床分離株におけるフルオロキノロン系抗菌薬耐性とチゲサイクリン耐性との関連性2017

    • Author(s)
      佐藤豊孝、品川雅明、髙橋聡、横田伸一
    • Organizer
      第91回日本感染症学会総会・第65回日本化学療法学会学術集会合同学会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2017-04-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] タゾバクタム/ピペラシリン耐性大腸菌の耐性機構の解析2017

    • Author(s)
      鈴木裕樹、佐藤豊孝、山本聡、小笠原徳子、白石宗、品川雅明、高橋聡、横田伸一
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台国際センター展示棟(宮城県仙台市)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大腸菌臨床分離株におけるフルオロキノロン系抗菌薬耐性とチゲサイクリン耐性との関連性2016

    • Author(s)
      佐藤豊孝、鈴木裕樹、山本聡、小笠原徳子、白石宗、品川雅明、髙橋聡、田村豊、横田伸一
    • Organizer
      第45回薬剤耐性菌研究会
    • Place of Presentation
      安芸グランドホテル(広島県廿日市)
    • Year and Date
      2016-10-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] タゾバクタム/ピペラシリン耐性大腸菌の耐性機構の解析2016

    • Author(s)
      鈴木裕樹、佐藤豊孝、山本聡、小笠原徳子、白石宗、品川雅明、高橋聡、横田伸一
    • Organizer
      第45回薬剤耐性菌研究会
    • Place of Presentation
      安芸グランドホテル(広島県廿日市)
    • Year and Date
      2016-10-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大腸菌臨床分離株におけるフルオロキノロン系抗菌薬耐性とチゲサイクリン耐性との関連性2016

    • Author(s)
      佐藤豊孝、鈴木裕樹、山本聡、小笠原徳子、 白石宗、品川雅明、高橋聡、田村豊、横田伸一
    • Organizer
      第10回細菌学若手コロッセウム
    • Place of Presentation
      草津セミナーハウス(群馬県草津市)
    • Year and Date
      2016-07-31
    • Related Report
      2016 Annual Research Report

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Published: 2015-08-26   Modified: 2018-03-22  

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