Research Project
Grant-in-Aid for Research Activity Start-up
In recent years, elucidation of crosstalk mechanisms of autophagy and apoptosis is a global trend in the field of cancer treatment. Since cancer cells are easy to acquire drug resistance and infiltration / metastasis ability, it is essential to develop therapeutic methods that take biodiversity into consideration. It is important to develop a combination therapy to efficiently induce cancer cell death by confirming whether autophagy is also called "double-edged sword" and whether it is beneficial for cancer cell survival. In this research project we examined rat kidney cancer cell line and highly lung metastatic lines and confirmed that combinations of drugs with various inhibitors in order to suppress or induce autophagy. Pharmacological methods were mainly used to address this problem and we hope to find a novel evidence in cancer therapeutics.
All 2017 2016 2015
All Journal Article (6 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 6 results, Open Access: 6 results, Acknowledgement Compliant: 3 results) Presentation (5 results)
In Vivo
Volume: 31 Pages: 187-197
Exp Toxicol Pathol
Volume: 69 Issue: 1 Pages: 1-7
10.1016/j.etp.2016.10.002
J Environ Sci
Volume: 49 Pages: 125-130
10.1016/j.jes.2016.07.005
Oncotarget
Volume: 7 Issue: 50 Pages: 83208-83222
10.18632/oncotarget.13079
PLoS One
Volume: 11 Issue: 7 Pages: e0158654-e0158654
10.1371/journal.pone.0158654
Cancer Sci
Volume: 107 Issue: 2 Pages: 123-132
10.1111/cas.12855
