| Project/Area Number |
15H06581
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied microbiology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Research Collaborator |
Okada Nobuhiko 北里大学, 薬学部, 教授
Mukai Takao 北里大学, 獣医学部, 教授
Yamamoto Yuji 北里大学, 獣医学部, 講師
Yokota Atsushi 北海道大学, 農学部, 教授
Fukiya Satoru 北海道大学, 農学部, 講師
Urashima Tadasu 帯広畜産大学, 畜産学部, 教授
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ビフィズス菌 / 定着 / プロバイオティクス / 付着因子 / ムチン / ミルクオリゴ糖 / シアリダーゼ / 細菌 / 糖鎖 / 付着 |
|---|
| Outline of Final Research Achievements |
Bifidobacterium is a natural inhabitant of the human gastrointestinal tract. I studied the role of sialidase (SiaBb2) from Bifidobacterium bifidum in gut colonization and carbohydrate catabolism. SiaBb2 cleaves sialyl-human milk oligosaccharides to produce usable oligosaccharides, thus supporting B. bifidum growth. Moreover, SiaBb2 promotes B. bifidum adhesion to mucosal surfaces. This study provides new insights into the role of B. bifidum sialidase as a bifunctional extracellular enzyme that is crucially important for B. bifidum colonization of the gut.
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