| Project/Area Number |
15H06584
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomolecular chemistry
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| Research Institution | Keio University |
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Principal Investigator |
Iwasaki Arihiro 慶應義塾大学, 理工学部(矢上), 助教 (00754897)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | クラハイン / 海洋天然物化学 / SERCA / プロヒビチン / 破骨細胞 / シアノバクテリア / 海洋天然物 / 天然物化学 / 生理活性 / 生体分子 / 小胞体ストレス / カルシウムイオン / 生物活性物質 |
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| Outline of Final Research Achievements |
Kurahyne is a marine natural product that exhibits osteoclast differentiation-inhibitory activity and sarco/endoplasmic reticulum Ca2+-ATPase (SERCA)-inhibitory activity. In this study, I have investigated the detailed mechanisms of these activities.
As a result, we have found the following things;
(1) Prohibitin-1 and -2 can play an important role in the osteoclast differentiation-inhibitory activity of kurahyne; (2) Specific fourteen amino-acid residues in SERCA are identified as a possible kurahyne-binding site; (3) Two kurahyne-related marine natural products were isolated, and the structure determination and the total synthesis of them were achieved. Furthermore, some knowledge regarding a structure-activity relationship was obtained.
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