| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Preterm birth is increasing in the world. Preterm babies develop erythropoietin (EPO)-deficiency anemia of prematurity (AOP). The cause of AOP has been unknown. Furthermore, the course of anemia during development also remained unclear.
We found that the cause of AOP is elevated oxygen levels in the kidney due to poor oxygen consumption by immature tubules. Our findings will help develop therapeutic options for AOP.
In addition, we reported EPO-induced polycythemia in adolescents born preterm with low birth weight. We considered that peritubular capillary rarefaction and progression of focal glomerulosclerosis were causes for the polycythemia.
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