| Project/Area Number |
15H06594
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 糖尿病 / 運動 / 網膜神経保護 / 網膜電図 / 糖尿病網膜症 / 眼科学 / 神経保護 |
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| Outline of Final Research Achievements |
We investigated the effect of exercise training on retinal function in type 2 diabetic mice. 8-week-old type 2 diabetic mice (db/db) and heterozygous controls (db/m) either underwent forced treadmill exercise training for 8 weeks. Visual function was analyzed by photopic and scotopic electroretinogram (ERG) at week 8, the end of the experimental protocol. The a-wave, b-wave, and OP amplitudes in scotopic ERG, and b-wave amplitudes in photopic ERG, which represents cone system function, were all reduced in the db/db sedentary groups compared with the db/m sedentary group at week 8. However, these changes in the db/db mice were attenuated by exercise. The db/m showed no difference in ERG responses with or without exercise.
Exercise training for 8 weeks preserved retinal function in db/db mice, suggesting that exercise may be a potential therapeutic approach to protect visual function in diabetes.
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