| Project/Area Number |
15H06606
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | Showa University |
|---|
Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 抗体設計 / 蛋白質工学 / データベース / 分子シミュレーション / バイオインフォマティクス / 抗体工学 / 構造予測 / 特異性 / 分子設計 / 生命情報科学 / 計算化学 |
|---|
| Outline of Final Research Achievements |
The vertebrate adaptive immune systems are capable of promoting cells to degranulate nearly any foreign pathogens by producing antibodies that recognize specific epitopes of antigens. Using existing crystal structures of protein complexes, we revealed peculiar features of various protein complex types, and we quantified shape complementarily of antibody-antigen interfaces. Exploiting docking simulations, we also revealed a stubborn gap in backbone motion not captured by any current computational approaches. Aiming for rational antibody design from amino acid sequences, we also developed antibody modeling methods. An antibody design based on those knowledges are underway.
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