Analysis of the role of reactive sulfur species in the chondrogenesis
| Project/Area Number |
15H06607
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 活性イオウ種 / 軟骨細胞 / 機能系基礎歯科学 |
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| Outline of Final Research Achievements |
Recently, RSS are polysulfer-containing compounds such as cysteine hydropersulfide and peptides/proteins harboring polysulfated cysteine residues.RSS provides superior antioxidation. Furthermore, RSS cause various bioactivity by modifying 8-nitro-cGMP which is one of the endogenous electrophile. As a result of this study, it was suggested that RSS was necessary for the extension of the mouse tibia. In addition, local existence of 8-nitro-cGMP with the mouse tibia growth plate cartilage and the tibial extension by 8-nitro-cGMP were accepted, too. It was suggested that RSS may become the new therapeutic drug for the cartilage disease.
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Report
(3 results)
Research Products
(2 results)
