Analysis of the role of reactive sulfur species in the chondrogenesis

Research Project

Project/Area Number	15H06607
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Functional basic dentistry
Research Institution	Showa University
Principal Investigator	Hoshino Marie 昭和大学, 歯学部, 助教 (10756464)
Project Period (FY)	2015-08-28 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	活性イオウ種 / 軟骨細胞 / 機能系基礎歯科学
Outline of Final Research Achievements	Recently, RSS are polysulfer-containing compounds such as cysteine hydropersulfide and peptides/proteins harboring polysulfated cysteine residues.RSS provides superior antioxidation. Furthermore, RSS cause various bioactivity by modifying 8-nitro-cGMP which is one of the endogenous electrophile. As a result of this study, it was suggested that RSS was necessary for the extension of the mouse tibia. In addition, local existence of 8-nitro-cGMP with the mouse tibia growth plate cartilage and the tibial extension by 8-nitro-cGMP were accepted, too. It was suggested that RSS may become the new therapeutic drug for the cartilage disease.