Development of Ceria-Stabilized Zirconia/Alumina implant
| Project/Area Number |
15H06609
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Showa University |
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Principal Investigator |
Oshima Yoko 昭和大学, 歯学部, 助教 (50756442)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯科インプラント / 歯科材料 / オッセオインテグレーション / 歯科材料学 / 歯科インプラント学 / 生体材料学 |
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| Outline of Final Research Achievements |
Ceria-stabilized zirconia/alumina nanocomposite (Ce-TZP/Al2O3) has been widely used for crowns and bridges. Since Ce-TZP/Al2O3 has low susceptibility to hydrothermal degradation, this material has potential to be applied to dental implant fixtures. The aim of this study was to development of Ce-TZP/Al2O3 implant, to investigate the osseointegration capability of the Ce-TZP/Al2O3 implant that was treated with hydrofluoric acid (HF) compared to that of acid-etched titanium implant.
Culture studies using MC3T3-E1 osteoblasts showed that the attachment, spread, and functional phenotypes of osteogenic cells, such as alkaline phosphatase activity, were remarkably increased on nanofeatured Ce-TZP/Al2O3 treated with HF. The strength of osseointegration measured by a biomechanical push-in test in a rat model was stronger for nanofeatured Ce-TZP/Al2O3 implants than for acid-etched titanium at week 2 and 4.
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Report
(3 results)
Research Products
(3 results)
