| Project/Area Number |
15H06626
|
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Nihon University (2016)
Teikyo University (2015) |
|---|
Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 口腔癌 / microRNA / ネットワーク解析 / microRNAアレイ解析 / 癌関連遺伝子 / microRNA アレイ解析 |
|---|
| Outline of Final Research Achievements |
We performed miRNA microarray analysis in oral squamous cell carcinoma (OSCC)-derived cell lines. We identified candidate microRNAs for molecular targeting. Our findings may contribute to an understanding of key biologic functions and pathways of certain microRNAs associated with OSCC, and the expression status of TGF-β may play an important role in the progression and prognosis of this disease. In addition, the differential expression status of TGF-β may provide insights into the process of tumorigenicity and for planning new treatment strategies
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