Study on the pathogenesis and drug metabolism of designer drug-related deaths
| Project/Area Number |
15H06628
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 危険ドラッグ / 横紋筋融解症 / セロトニン症候群 |
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| Outline of Final Research Achievements |
We reported on the first lethal case of 25B-NBOMe, a law-evading (dangerous) drug, which presented with symptoms of serotonin syndrome including hyperthermia and rhabdomyolysis. Accordingly, we administered 25B-NBOMe at 5ng/kg～10mg/kg i.p. in rats, but could not reproduce the syndrome. However, we could reproduce rhabdomyolysis in zebrafish. Therefore, we planned to clarify the mechanism underlying the rhabdomyolysis.
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Report
(2 results)
Research Products
(1 results)
